The invention provides an efficient and safe automatic durian packaging machine, and belongs to the technical field of agricultural and sideline product packaging. Due to the fact that a durian shellis hard and is inconvenient to package and the durian shell is provided with spikes, the problem that people are prone to being damaged is solved. The packaging machine comprises a working table, a speed reducing motor, a guide machine, four supporting legs are arranged on the lower surface of the working table, a transverse pulling plate is fixedly arranged between the supporting legs, the uppersurface of the transverse pulling plate is provided with the speed reducing motor, a lifting mechanism is arranged on the upper surface of the working table, a third stand column is arranged on the upper surface of the working table, a film roll is placed on the third stand column, a fourth stand column is arranged on the surface of the working table, and a pressing mechanism is arranged on the surface of the fourth stand column. According to the efficient and safe automatic durian packaging machine, the durian is driven to rotate by the speed reducing motor, so that manual output is reduced,and the packaging efficiency of the durian is improved; and the durian is packaged through a paperboard, so that the durian can be protected well, a hard spiked shell on the surface of the durian canbe effectively prevented from stabbing workers, and the durian packaging is safer and more reliable.