The invention belongs to the technical field of shaft part plastic forming equipment, and particularly relates to an intelligent guide and guard device of a large axle wedge cross rolling mill for rail transit. The intelligent guide and guard device comprises guide and guard brackets, guide and guard bases arranged below the guide and guard brackets, and a guide and guard cross beam is arranged between the two guide and guard brackets. A plurality of guide and guard hydraulic cylinders are arranged on the guide and guard beam, telescopic rods of the guide and guard hydraulic cylinders are connected with a guide and guard sliding seat, guide and guard sliding grooves are formed in the inner sides of the guide and guard brackets, the guide and guard sliding seat is clamped in the guide and guard sliding grooves, and two adjusting hydraulic cylinders are installed on the front side of the guide and guard sliding seat. The upper ends of the two adjusting hydraulic cylinders are jointly hinged to a guide plate base. According to the intelligent guide and guard device of the large axle wedge cross rolling mill for rail transit, intelligent adjustment of the guide and guard device is achieved through a control system, the guide and guard hydraulic cylinders, the adjusting hydraulic cylinders, clamping hydraulic cylinders and a detection device, and the front opening, the rear opening and the height of the guide and guard device can be rapidly and intelligently adjusted according to product specifications, and the inclination angle of a guide plate can be manually adjusted.