The invention discloses a target node key information filling method and system based on an association network, and belongs to the technical field of data mining, machine learning and graph theory. The problem of low accuracy of the filled key information of the target node in the prior art is solved. According to an application scene, the method comprises steps of establishing a relational network of a large number of nodes; based on network relation, obtaining an association network of a target node with key information, integrating the association network into a data structure comprising atarget node, a label, an association node, an association node weight and an attribute vector, performing multiple three-dimensional sampling on the data structure based on an improved random forestmethod to obtain a subset of a plurality of training decision trees, giving a plurality of decision trees to perform training, and performing integration after training to obtain a final model; and based on the associated nodes of the to-be-filled target node, performing prediction through the final model, and performing weighted average on multiple results after prediction to obtain final fillinginformation. The key information of the target node is filled based on the association network.