The invention discloses a no-signal intersection vehicle and vehicle cooperative collision prevention system, which comprises a wireless communication module, a central processing unit, a vehicle running state information collecting module, a driving intention judging module, a man-machine interaction interface, a brake control module and a power supply management module. According to the system, information such as self vehicle position, speed, acceleration and the like are collected by the vehicle running state collecting module, and the self vehicle running state is obtained; the vehicle turning information is collected through the driving intention judging module, and the driving intention of a driver is judged; the self vehicle information is sent out to the periphery by the wireless communication module in a broadcasting way, and the running state information of surrounding vehicles is received; the central processing unit is connected with the vehicle running state information collecting module, the driving intention judging module and the wireless communication module, information of the self vehicle and other vehicles is obtained, the collision judgment and the disposition are carried out, the collision occurrence is judged, the vehicles are controlled to be braked through the brake control module, and early warning signals are given to the driver through the man-machine interaction interface; the man-machine interaction interface can also control the starting and the stop of the system; and the power supply management module provides power supply for each module of the system.