53 results about "Collagen hydrolysates" patented technology

The invention relates to method for obtaining collagen from animal sources such as fresh or saltwater fish, chicken, eggs or from parts of these animal sources that can be considered waste, and to a collagen hydrolysate obtained as a result of this method.

Pet food compositions, and particularly, pet food compositions comprising fish collagen hydrolysate are disclosed herein. Also disclosed herein are methods of treating an immune disorder, such as atopic dermatitis in a companion animal in need thereof and methods of alleviating at least one of pruritus, erythema, or alopecia in a companion animal with atopic dermatitis.

The invention relates to the technical field of biological active peptides, in particular to a method for rapidly and effectively screening light protection active peptides from collagen hydrolysate. The invention relates to an application of a photoprotective polypeptide in preparation of a product. The product has at least one of the following purposes: (1) maintaining or increasing the water content of skin; (2) preventing and / or slowing down skin aging; (3) prevention and / or alleviation of skin UVB injury; and (4) promoting healing of skin wounds or wound surfaces. Two key signal factors (NF-kB, AP-1) and a key matrix metalloproteinase (MMP-9) are screened from a mitogen-activated protein kinase (MAPK) and nuclear factor-kB (NF-kB) pathway to be used as docking targets, and a mimic peptide and the three targets act synergistically to make up for the defect that a single target screening peptide is difficult to comprehensively cope with a light damage multivariate pathway, so that the application of the mimic peptide to the light damage multivariate pathway is realized, and the application of the mimic peptide to the light damage multivariate pathway is realized. And the collagen peptide with excellent light protection activity is obtained through screening.

The invention belongs to the field of biology, particularly relates to a preparation method, a composition and application of yak bone collagen hydrolysate capable of preventing and treating osteoporosis, and further provides an oral liquid composition which comprises the following raw materials in percentage by mass: 6% of yak bone collagen hydrolysate, 2% of glucosamine sulfate, 0.4% of chondroitin sulfate and the balance of water. The yak bone collagen hydrolysate and oral liquid composition prepared by the method can improve pathological changes of bone tissues of mice with osteoporosis, promote regeneration of collagen in osteoporosis tissues, improve BMD, BV / TV, Tb.N and Tb.Th of cortical bones, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, improve osteoporosis, and improve osteoporosis. The Tb.Sp and Po of cortical bones are reduced, and the excellent function of preventing and treating osteoporosis is achieved.

The present invention relates to a use of collagen hydrolysate after intensive care unit (ICU) stay. The collagen hydrolysate improves the recovery and prevents and / or treats post intensive care syndrome (PICS) after ICU stay. The collagen hydrolysate is preferably administered as a supplement in the context of ICU stay and / or PICS. Collagen hydrolysate is generally-accepted to be safe and therefore can be taken as a preventive and long-term measure.

The invention discloses an application of two collagen peptides with hematopoietic activity, a collagen hydrolysate containing the collagen peptides and a compound of the collagen peptides. The collagen peptides with hematopoietic activity, the collagen hydrolysate containing the collagen peptides and the compound of the collagen peptides comprise one or a combination of the following polypeptides: 1) a polypeptide of GSAGPpGATGFpGAAGR (p is hydroxyproline), and 2) a polypeptide of which the amino acid sequence is GAAGLpGPK (p is hydroxyproline). The invention also provides a preparation method and application of the collagen peptide with hematopoietic activity and the collagen hydrolysate containing the collagen peptide, the two collagen peptides with hematopoietic activity and the compound thereof have good hematopoietic activity and an effect of relieving hematopoietic inhibition, are non-toxic, can be easily used as functional factors to be added into various health-care foods, and have good health-care effects. Good market prospects are realized in medicine and food industries.

The invention provides a bovine type I collagen terminal end peptide characteristic polypeptide, the bovine type I collagen terminal end peptide characteristic polypeptide comprises an N terminal end peptide characteristic polypeptide and a C terminal end peptide characteristic polypeptide, the amino acid sequence of the N terminal end peptide characteristic polypeptide is Q * LSYGYDE, and the amino acid sequence of the C terminal end peptide is LSFLPQPPQE. The invention also provides application of the bovine type I collagen terminal peptide marker polypeptide in detection of N-terminal peptide and C-terminal peptide of bovine type I collagen. The invention also provides a preparation method of a collagen enzymolysis product containing the bovine type I collagen terminal peptide characteristic polypeptide. The bovine type I collagen tail end terminal peptide marker polypeptide provided by the invention is a special terminal peptide at the tail end of bovine type I collagen. The terminal peptide marker polypeptide is used as a marker and can be used for quickly identifying the bovine type I collagen terminal peptide and accurately and quantitatively analyzing the bovine type I collagen terminal peptide. The qualitative and quantitative detection methods are simple to operate and high in sensitivity.

The present invention pertains to a cyclic(glycine-proline)-enriched peptide composition and the use thereof particularly for ameliorating neurological conditions or fibrosis. The present invention furthermore pertains to a method for obtaining a peptide composition enriched in cyclic(glycine-proline), the method comprising providing a collagen hydrolysate enriched in gly-pro-x tripeptides, and heat-treating the collagen hydrolysate to allow cyclization of at least part of the gly-pro-x tripeptides to cyclic(glycine-proline).

To provide a collagen hydrolysate for improving endurance performance and / or for stimulating lipid metabolism.SOLUTION: The present invention relates to the use of a collagen hydrolysate for improving endurance performance by increasing mitochondrial activity. Further, the invention relates to the use of a collagen hydrolysate for stimulating lipid metabolism, and in particular for reducing body weight, by increasing mitochondrial activity.SELECTED DRAWING: Figure 1

The invention discloses an extraction method of ganoderma lucidum outer vesicles, the ganoderma lucidum outer vesicles and application of the ganoderma lucidum outer vesicles, and relates to the technical field of extraction methods of plant extracellular vesicles. The extraction method comprises the following steps: inoculating a lucid ganoderma activated strain into a liquid fermentation culture medium for liquid fermentation culture to obtain lucid ganoderma fermentation liquor; carrying out solid-liquid separation on the ganoderma lucidum fermentation liquor to obtain a ganoderma lucidum outer vesicle crude extract; the ganoderma lucidum outer vesicle crude extract is subjected to resuspension precipitation and centrifugal treatment, and ganoderma lucidum outer vesicles are obtained; the liquid fermentation culture medium is prepared from the following components: glucose, maltodextrin, glycerol, a yeast extract, a type III collagen hydrolysate, a grape pomace extract, KH2PO4, Mg2SO4. 7H2O, Ca3 (PO4) 2, FeSO4. 7H2O, ZnSO4. 7H2O, vitamin B1, vitamin B2, chitosan and a surfactant. The method has the advantages that the yield of the ganoderma lucidum outer vesicles is high, the purification method is simple, and the production efficiency is high.

The invention discloses a high-hydrolysis-degree small-molecular-weight deer sinew collagen peptide and a preparation method thereof. The preparation method comprises the following steps: (1) extracting deer sinew collagen; (2) performing ultrahigh-pressure pretreatment on the deer sinew collagen hydrolysate obtained in the step (1) to obtain ultrahigh-pressure deer sinew collagen liquid, and performing enzymolysis by using alkaline protease under the ultrahigh-pressure treatment conditions that the pressure is 100-400 MPa, the treatment time is 10-40 minutes and the enzyme addition amount of the alkaline protease is 1000-1200 U / g; and (3) the deer sinew collagen hydrolysate obtained in the step (2) is subjected to secondary enzymolysis with flavourzyme, the deer sinew peptide with the high hydrolysis degree is obtained, and the enzyme addition amount of the flavourzyme is 800-1000 U / g. According to the preparation method, the deer sinew collagen peptide is prepared by adopting ultrahigh-pressure synergetic double-enzyme enzymolysis, the spatial conformation of the deer sinew collagen is changed through high-pressure pretreatment, the deer sinew collagen peptide is prepared by synergetic double-enzyme enzymolysis, the hydrolysis degree is remarkably improved, and the low-molecular-weight collagen peptide is accurately enriched.

The present invention relates to a method for increasing the efficiency of a solar module or a solar collector, wherein the solar module or the solar collector comprises a glass pane on the side that faces toward the sun. The method comprises the steps of applying an aqueous solution of collagen hydrolysate to the glass pane and allowing the aqueous solution to dry.

(Main claim): A food supplement comprising collagen hydrolysate and a combination of vitamin C, zinc, vitamin E, silicon dioxide and copper, characterized in that the components are in a composition that causes rapid and uniform dispersion in aqueous liquids and improved bioavailability of the collagen hydrolysate.

The invention relates to the technical field of after-finishing processing of textiles, and discloses a biological finishing liquid and a finishing method for resisting fuzzing and pilling of fabrics. The biological finishing liquid contains collagen hydrolysate, epoxy resin, a softening agent and a solvent. The invention also discloses an anti-pilling finishing method for the fabric, which comprises the following steps: contacting the fabric with the biological finishing liquid, and drying, the biological finishing liquid contains collagen hydrolysate, epoxy resin, a softening agent and a solvent. When the biological finishing liquid is used for finishing the fabric, the anti-pilling property of the fabric can be improved, and meanwhile, the good hand feeling of the fabric is ensured.

The invention provides a novel method for efficiently extracting and preparing collagen by taking bullfrog skin as a raw material. The process comprises the following steps. The preparation method comprises the following steps: 1) removing impurities from bullfrog skin, cleaning, chopping and homogenizing, stirring and soaking the bullfrog skin with an alkaline solution to remove grease and non-collagen in the bullfrog skin, and washing the bullfrog skin with pure water until the bullfrog skin is neutral; the preparation method comprises 1) preparing collagen powder, 2) hydrolyzing with pepsin and an acetic acid solution, and filtering to obtain a collagen hydrolysate, 3) precipitating to remove macromolecules and non-collagen containing pigment in the collagen hydrolysate by an alkali precipitation method, and centrifuging or filtering to obtain a collagen extracting solution, and 4) concentrating the collagen extracting solution by a membrane, and freeze-drying to obtain the high-purity collagen powder.

This invention discloses a skin-friendly, hypoallergenic composite functional fiber, its preparation method, and its applications, relating to the field of functional textile materials technology. This invention utilizes transglutaminase (TG enzyme) to catalyze the formation of transamide covalent complex macromolecules from chitosan and gelatin, collagen, or collagen hydrolysates. These macromolecules are then blended with spinning dosing and introduced in situ into the fiber matrix through a spinning process. This ensures the functional components are uniformly distributed across the fiber cross-section and surface, forming a continuous, stable, and biocompatible skin-friendly protective film on the fiber surface. Through application, structural, and process innovations, this invention solves the problems of poor wash resistance, easy functional loss, and skin irritation in traditional hypoallergenic textiles. The resulting fiber exhibits long-lasting allergen adsorption, hypoallergenic skin-friendliness, antibacterial and soothing properties, and high wash resistance, making it suitable for intimate apparel, baby products, home textiles, and medical protective textiles.

Pet food compositions, and particularly, pet food compositions comprising fish collagen hydrolysate are disclosed herein. Also disclosed herein are methods of treating an immune disorder, such as atopic dermatitis in a companion animal in need thereof and methods of alleviating at least one of pruritus, erythema, or alopecia in a companion animal with atopic dermatitis.

The application discloses poultry-derived characteristic collagen peptides and application thereof in detection of collagen hydrolysate and products thereof, and belongs to the field of detection. The characteristic collagen peptides are Gly-Leu-Val-Gly-Glu-Hyp-Gly-Pro-Ala-Gly-Ala-Lys, Gly-Glu-Gly-Gly-Pro-Ala-Gly-Pro-Ala-Gly-Pro-Ala-Gly-Ala-Arg and Val-Gly-Pro-Ile-Gly-Pro-Ala-Gly-Asn-Arg, and whether poultry-derived components are contained is determined by detecting one or more characteristic collagen peptides. The characteristic collagen peptides are freed by trypsin enzyme cutting on protein components in a sample, and are detected by a liquid chromatograph-mass spectrometer. The method is characteristic and high in sensitivity, and can be used for determination of poultry-derived components in collagen hydrolysate and products thereof.

Pet food compositions, and particularly, pet food compositions comprising fish collagen hydrolysate are disclosed herein. Also disclosed herein are methods of treating an immune disorder, such as atopic dermatitis in a companion animal in need thereof and methods of alleviating at least one of pruritus, erythema, or alopecia in a companion animal with atopic dermatitis.

The present invention relates to a composition comprising chondroitin sulfate and collagen hydrolysate, for use in ameliorating pain, preferably for use in ameliorating joint pain after exercise. The present invention furthermore relates to a method of preparing said composition by hydrolysis of a collagen-containing material comprising different types of collagen. The composition is preferably administered as a food supplement.

The present invention relates to the use of collagen hydrolysate in the prevention and / or treatment of food craving. The collagen hydrolysate may have a therapeutic and / or non-therapeutic effect. The prevention and / or treatment of craving by the collagen hydrolysate may find purpose in losing bodyweight or improving general well-being. The collagen hydrolysate is preferably administered as a daily food supplement formulation.

The present invention relates to an application of collagen hydrolyzate in the preparation of a product for improving the acid resistance and / or bile salt resistance and / or proliferation activity of probiotics, a method for improving the acid resistance and / or bile salt resistance and / or proliferation activity of probiotics, and a probiotic product. On the basis of the collagen hydrolyzate providing growth factors for probiotics (such as Lactobacillus rhamnosus), the collagen hydrolyzate is added under acidic and bile salt culture medium conditions to significantly improve the growth activity of Lactobacillus rhamnosus, and can improve the activity of probiotics (such as Lactobacillus rhamnosus) in gastric juice and intestines when ingested.

The present invention relates to a cryopreserved formulation comprising a collagen hydrolysate and preferably comprising dimethyl sulfoxide. The invention also relates to a method for cryopreservation of one or more biological substances, said method comprising the step of providing one or more biological substances in a cryopreserved formulation comprising a collagen hydrolysate and preferably dimethyl sulfoxide. The invention also relates to the use of a cryopreservation formulation comprising a collagen hydrolysate and preferably dimethyl sulfoxide for cryopreservation of one or more biological substances selected from the group consisting of eukaryotic cells, prokaryotic cells, organelles, extracellular vesicles, organoids, tissues and organs. The invention also relates to the use of the collagen hydrolysate, preferably the collagen hydrolysate combined with dimethyl sulfoxide, in the preparation of a cryopreservation preparation.

The present invention relates to a collagen hydrolysate for use as an active substance in the treatment of neurodermatitis.

The present invention pertains to a cyclic(glycine-proline)-enriched peptide composition and the use thereof particularly for ameliorating neurological conditions or fibrosis. The present invention furthermore pertains to a method for obtaining a peptide composition enriched in cyclic(glycine-proline), the method comprising providing a collagen hydrolysate enriched in gly-pro-x tripeptides, and heat-treating the collagen hydrolysate to allow cyclization of at least part of the gly-pro-x tripeptides to cyclic(glycine-proline).

The present invention relates to a composition comprising chondroitin sulfate and collagen hydrolysate, for use in ameliorating pain, preferably for use in ameliorating joint pain after exercise. The present invention furthermore relates to a method of preparing said composition by hydrolysis of a collagen-containing material comprising different types of collagen. The composition is preferably administered as a food supplement.

The application discloses a preparation method of a nano-limited enhanced biomass-based room-temperature phosphorescent material, and specifically comprises the following steps: step 1, white skin powder is added into deionized water, and the pH in the system is adjusted by using a sodium hydroxide solution, and the system is magnetically stirred under heating; after being cooled to room temperature, centrifugation is carried out, and a supernatant, namely a collagen hydrolysate solution, is obtained; step 2, under stirring, two-dimensional layered nanosheets are added into the collagen hydrolysate solution obtained from step 1 and stirred to obtain a transparent solution; and step 3, the transparent solution obtained from step 2 is naturally dried, a light yellow solid is obtained, and grinding is carried out to obtain a two-dimensional layered nano-limited induced enhanced biomass-based room-temperature phosphorescent material. The application further discloses the nano-limited enhanced biomass-based room-temperature phosphorescent material and application thereof. The application solves the problem that the existing water-phase RTP material cannot meet diversified application requirements (anti-counterfeiting and information encryption).

The present invention relates to the use of collagen hydrolysate in the prevention and / or treatment of food cravings. Collagen hydrolysate may have therapeutic and / or non-therapeutic effects. The prevention and / or treatment of cravings with collagen hydrolysate may be aimed at reducing weight or improving general well-being. Collagen hydrolysate is preferably administered as a daily food supplement formulation.

The present invention relates to a method for manufacturing a paper having improved impermeability to grease and oil, comprising the following steps: (a) providing a paper with a first surface and a second surface; (b) applying an aqueous solution to the first surface, wherein the aqueous solution comprises from approximately 10 to approximately 50 weight % of collagen hydrolysate and at least approximately 0.1 weight % of a plasticizer; (c) drying the aqueous solution in order to obtain a coating comprising collagen hydrolysate and plasticizer on the first surface.

The present invention relates to a cryopreservation preparation comprising collagen hydrolysate, preferably comprising dimethyl sulfoxide.The present invention further relates to a method for cryopreserving one or more biological materials, comprising providing one or more biological materials in a cryopreservation preparation comprising collagen hydrolysate and preferably dimethyl sulfoxide.The present invention also relates to the use of a cryopreservation preparation comprising collagen hydrolysate and preferably dimethyl sulfoxide for cryopreserving one or more biological materials selected from the group consisting of eukaryotic cells, prokaryotic cells, cell organelles, extracellular vesicles, organoids, tissues, and organs.The present invention also relates to the use of collagen hydrolysate in a cryopreservation preparation, preferably in combination with dimethyl sulfoxide.