The invention discloses an ethyl Spinosad-containing pesticide compound. The compound comprises of two effective constituents of ethyl Spinosad and diafenthiuron, an auxiliary agent, and solvent or acarrier, wherein the ratio of the ethyl Spinosad and diafenthiuron is between 50:1 and 1:50 by weight, and the total weight content of the effective constituents are 1% to 80%. The compound has a substantial synergy effect, enlarges the control spectrum, is helpful for overcoming and delaying the pesticide resistance of the pests, and has better compatibility with the environment. The compound can control the Lepidoptera, homoptera, thysanoptera pests and the like on the rice, barley, cotton, fruit tree, and vegetable with high efficiency, is especially used for controlling high resistance pests like beet armyworm, diamondback moth, common thriops, whitefly, pea leaf fly, rice leaf roller, smaller green leafhopper, and the like with an effect obviously better than that of using a single agent thereof.