The invention relates to an anti-
cancer drug slow release injection containing
gemcitabine, which comprises slow release microspheres and a menstruum, wherein the
microsphere comprises anti-
cancer active ingredients and slow release auxiliary materials, and the menstruum is a special menstruum containing a suspending agent; the anti-
cancer active ingredients are
gemcitabine, or antimetabolites selected from zalcitabine,
emtricitabine, galocitabine, ibacitabine, ancitabine,
decitabine, flurocitabine, enocitabine,
imidazole gemcitabine,
capecitabine, gemcitabine, fludarabine or
cladribine, and / or
antimetabolite potentiating agents selected from phosphoinositide 3-
kinase inhibitor,
pyrimidine analogue and / or
DNA repair enzyme inhibitor; the slow release auxiliary materials are polifeprosan, dienoic
fatty acid,
decanedioic acid copolymer,
polylactic acid copolymer, EVAc and the like; the suspending agent has a
viscosity of 100cp-3000cp (20-30 DEG C), and is selected from
sodium carboxymethylcellulose and the like. The slow release microspheres can be prepared into slow release implants. When injected or placed into tumors or at peripheries of tumors, the slow release microspheres can enhance the
treatment effect of non-operative treatment methods, such as radiotherapy,
chemotherapy, etc.