4 results about "Protein stabilization" patented technology

The present application relates to the field of agrochemical adjuvants, and relates to an agrochemical protein adhesion synergist based on a plant-derived protein, and a preparation method therefor and a use thereof. Said synergist comprises the following raw materials in parts by weight: 20-500 parts of a plant-derived protein, 50-450 parts of a protein dispersant, and 20-350 parts of a protein stabilization and protection agent. The product of the present application improves the utilization rate of agrochemicals and reduces problems such as grain yield reduction and environmental pollution caused by the loss of agrochemicals. Moreover, as the protein degrades into amino acids, plant growth can be promoted, and the resistance of plants to abiotic stress is improved, thereby reducing dosage of agrochemicals while enhancing efficacy of agrochemicals.

Enzymatic compositions having enhanced thermal stability comprise an enzyme, a polymeric charged molecule having a charge opposite a charge of the enzyme, and a zwitterionic stabilization agent. Methods for enhancing thermal stability of an enzyme are also provided and include steps of combining an enzyme with one or more of a polymeric charged molecules having a charge opposite a charge of the enzyme and a zwitterionic stabilization agent. Methods for treating a wound are also provided and include administering to a subject an effective amount of an enzymatic composition.

Deubiquitinase-targeting chimeras (DUBTACs) are an emerging class of therapeutics that can stabilize tumor suppressors by hijacking a deubiquitinase (DUB), thereby offering a strategic pivot from conventional approaches to target tumor suppressors. However, only OTUB1 and USP7 have been harnessed for DUBTAC development to date. Here, we show for the first time that USP28 can be leveraged for developing DUBTACs. Utilizing a USP28 non-covalent ligand, we crafted USP28-recruiting DUBTACs that effectively stabilized the ΔF508-CFTR mutant protein, with comparable effectiveness to the previously reported OTUB1- and USP7-recruiting CFTR DUBTACs. Furthermore, we developed USP28-recruiting cGAS DUBTACs that effectively stabilized cGAS, elevated the cGAS-STING signaling pathway, and elicited an anti-proliferative effect. We also developed first-in-class PPARγ DUBTACs to intervene with cancer metabolism pathways. Our lead PPARγ DUBTACs effectively stabilized PPARγ and suppressed the proliferation in cancer cells, thus providing a new potential anti-cancer therapeutic approach. Hence, this work advances the targeted protein stabilization field.

The present invention relates to a protein-stabilized liquid formulation and provides: a composition for protein stabilization, the composition including a stabilizer and a surfactant and not including a buffer; a protein liquid composition including the composition for stabilization and a protein; and a method of producing a protein-stabilized liquid composition which uses the composition for stabilization.