The invention provides a flexographic printing proofing press based on intelligent operation, and relates to the technical field of flexographic printing, the flexographic printing proofing press comprises a proofing press main body, side guide rails are arranged on the two sides of the proofing press main body, a movable operation frame is arranged on the side guide rails, and a lifting connecting beam is installed in the movable operation frame; a lifting motor is fixedly connected to the upper portion of the movable operation frame, a lifting chain is installed in the movable operation frame, the lifting motor is connected with and drives the lifting chain, the two ends of a lifting connecting beam are fixedly connected with connecting beam sliding blocks, and the automatic replacement function of a scraper, an ink disc, an anilox roller and a plate roller is achieved. The scraper, the ink disc, the anilox roller and the plate roller do not need to be manually operated, the labor intensity of operators is reduced, the operation efficiency is improved, and the problems that in the prior art, when different products are printed through the same flexographic printing proofing press, replacement of the scraper, the ink disc, the anilox roller and the plate roller needs to be manually completed, the labor intensity of the operators is high, and the working efficiency is high are solved. And the operation efficiency is low.