The invention discloses a method for making a paper adhesive seal lose efficacy in a lossless manner. Firstly, the side, sealed with adhesive, of a paper adhesive seal end is infiltrated with an appropriate amount of water molecules equivalent to a paper material and thethickness, and except for the side sealed with adhesive, remaining portions are maintained in the original state; secondly, a paper adhesive seal end infiltrated position is shielded with a waterproof material, wherein the escaping amount of the water molecules into air in the microwave radiating process does not exceed 50%; and thirdly, a seal position is placed in the microwave environment, wherein the microwave frequency is 2.45 GHz to 7.5 GHz, the output power is 200 W-900 W, the acting time is 10seconds-60 seconds, andafter the shielding matter is removed, cure adhesive at the seal position is transformed to be ina wet glue state, the infiltrated side of the paper adhesive seal end is dried and free of deformation, and the paper adhesive seal can be opened in a lossless manner under the effect of the external force. Due to the method, an efficiency losing method of paper adhesive is effectively simplified, theoperation time is shortened, and controllability in the process is improved.