38results about How to "Guaranteed stable action" patented technology

The present invention provides therapeutic agents and compositions comprising elastic peptides and therapeutic proteins. Such peptides exhibit a flexible, extended conformation. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist (e.g., GLP-1, exendin), insulin, or Factor VII / VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and / or persistence in the body, solubility, and bioavailability.

A protein comprising (I) an anti-CD14 antibody or its active fragment, or a derivative thereof and (II) an inhibitor for a protease, or its active fragment, or a derivative thereof is provided.

A detection switch mounted in a card socket including contact members responsive to insertion of a card into the card socket. The switch includes two or more contact members of the same design, each contact member having a switch contact formed on opposite ends. The switch contact at one end has a front contact section formed in the card width-parallel plane defining a first switch contact. The switch contact at the other end has a rear contact section formed in the card thickness-parallel direction and defines a second switch contact in confronting relation with the first contact. Insertion of the card in the card socket causes the first switch contact to move in the card width-parallel plane toward the second switch contact in the card thickness-parallel direction so that the second contact is contacted and wiped by the first contact.

The invention provides a wafer holding apparatus which enables ascertainment of gripping and presence / absence of a wafer through use of single detection means.The apparatus has drive means (2) having a pressing element (8) which advances or recedes in a longitudinal direction; and detection means (9) for detecting advancement / receding of the pressing element (8). When the detection means (9) has detected that the pressing element (8) has advanced to and come to a halt at a predetermined position, the wafer is determined to be properly held. When the detection means (9) has detected that the pressing element (8) has advanced in excess of the predetermined position, the wafer is determined not to be present on the wafer holding apparatus.

A ramp loading unit includes a holding part that holds a head support part at a position apart from a record carrier, the head support part supporting a head that records information in and reproduces the information from the record carrier, a sliding part which the head support part elastically contacts when the head is to be loaded over the record carrier and the head is to be unloaded from the record carrier; and a member that changes a contact position on the head support part with the sliding part when the head support part slides on the sliding part.

A protein comprising (I) an anti-CD14 antibody or its active fragment, or a derivative thereof and (II) an inhibitor for a protease, or its active fragment, or a derivative thereof is provided.

The ink in a printing press, in which a stock of material is being printed in an ongoing printing process, is registered. At least one ink is applied to the stock in several inking zones. A measured value, indicating an ink density, is determined for the at least one ink which is being applied to the stock in the printing process and within the printing press. A relation is formed between the measured ink density for a specific ink in a selected ink zone and a measured ink density value determined for the same ink in at least one other inking zone. The relation between the measured ink density values in different inking zones is formed only if the majority of the inking zones of a specific inking unit of the printing press supply one respective measured ink density value for an ink supplied by that inking unit, and when the measured ink density value reaches at least a predetermined fraction of a preset, desired value in the respective inking zone.

The ink in a printing press, in which a stock of material is being printed in an ongoing printing process, is registered. At least one ink is applied to the stock in several inking zones. A measured value, indicating an ink density, is determined for the at least one ink which is being applied to the stock in the printing process and within the printing press. A relation is formed between the measured ink density for a specific ink in a selected ink zone and a measured ink density value determined for the same ink in at least one other inking zone. The relation between the measured ink density values in different inking zones is formed only if the majority of the inking zones of a specific inking unit of the printing press supply one respective measured ink density value for an ink supplied by that inking unit, and when the measured ink density value reaches at least a predetermined fraction of a preset, desired value in the respective inking zone.

An integrated electronic hydraulic brake system provided with an actuator including a master cylinder and a pedal simulator, an electronic stability control (ESC) and a hydraulic power unit (HPU) in a single unit.

In a capacity control valve, a discharged-fluid-receiving part having a diameter that is larger than the diameter of a valve hole interconnecting a first valve chamber and a third valve chamber is provided to the outer periphery section of a third valve part. It is thereby possible to obtain a capacity control valve in which, when the first valve part opens, the discharged-fluid-receiving part receives the pressure of the discharged fluid, the actuation response of the valve body during an opening action is moderated, an excessive increase in the sensitivity to a rise in pressure in the crank chamber caused by a rapid increase in the amount of coolant flowing into the crank chamber is prevented, and the action of the valve body is stable.

A light quantity adjusting device includes a substrate having an optical path aperture, a blade located on the substrate to adjust the quantity of light passing through the optical path aperture, and an electromagnetic driver that drivingly opens and closes the blade. The electromagnetic driver includes a rotor shaft, an exciting coil, and a frame that rotatably bears the rotor shaft. The rotor shaft includes a pointed first shaft end and a cylindrical second shaft end. The frame has a conical bearing recess that supports the first shaft end and a cylindrical bearing hole that supports the second shaft end. The electromagnetic driver is located so that the first shaft end of the rotor shaft is closer to the substrate than the second shaft end. An arm is coupled to the first shaft end of the rotor shaft to transmit an opening and closing driving force to the blade.

A switching power supply circuit has a current mode control circuit including current detection means, and current mode signal generation means for generating a current mode signal being a drain current of a first MOS transistor obtained by supplying a first current information signal, which is an output signal of the current detection means, to the gate of the first MOS transistor, and by connecting a first resistance to the source of the first MOS transistor, and supplies the current mode signal to a feedback control system of the switching power supply circuit.

An electromotive linear drive, in particular for adjusting movably mounted parts of lounging and seating furniture, has a drive motor, a threaded spindle, a speed-reducing gear unit arranged between the drive motor and the threaded spindle, and a spindle nut (9) located on the threaded spindle. The spindle nut is optionally lockable in the direction of rotation and movable in the axial direction of the threaded spindle, depending on the direction of rotation of the threaded spindle. A lifting element can be driven by the axial movement of the spindle nut to adjust the movable furniture parts. Such a linear drive has a simple design, is easy to assemble and operate, and guarantee a robust mounting arrangement for the drive parts.

A bootstrap circuit for a step-down chopper regulator IC includes an LDMOS transistor having a gate and a source connected to output terminals of a constant voltage circuit and a drain connected to a leader terminal of a boot voltage, and a bootstrap control circuit that performs control of turning on and off the LDMOS transistor so as to support high-speed oscillation without requiring expensive process and realize a stable step-down chopping action with a wide input voltage range.

A bootstrap circuit for a step-down chopper regulator IC includes an LDMOS transistor having a gate and a source connected to output terminals of a constant voltage circuit and a drain connected to a leader terminal of a boot voltage, and a bootstrap control circuit that performs control of turning on and off the LDMOS transistor so as to support high-speed oscillation without requiring expensive process and realize a stable step-down chopping action with a wide input voltage range.

A disc-shaped optical record carrier includes a first area having a spiral track extending in a first direction from an inner side on the disc, and a second area having a spiral track extending in a second direction opposite to the first direction, from an outer side on the disc located on the same plane as the first area on the disc, wherein one of the first and second areas is assigned a recordable area and the other is assigned a read only area.

Provided is a semiconductor memory, comprising: a voltage converting circuit which voltage-converts a resistance difference between a first and a second resistance elements; a voltage comparing circuit which outputs an output corresponding to the voltage conversion; a latch circuit for holding the output of the voltage comparing circuit; and a switch circuit which cuts and connects the voltage converting circuit and the voltage comparing circuit.

Provided is a semiconductor memory, comprising: a voltage converting circuit which voltage-converts a resistance difference between a first and a second resistance elements; a voltage comparing circuit which outputs an output corresponding to the voltage conversion; a latch circuit for holding the output of the voltage comparing circuit; and a switch circuit which cuts and connects the voltage converting circuit and the voltage comparing circuit.

The plausibility of at least one measured value, that is determined in a printing press, and that includes a density of an ink applied to a stock, is assessed. The stock is conveyed through the printing press and the ink is applied to the stock in several inking zones. A relation is formed between a measured ink density value, which is determined for a specific ink in a selected ink zone, and a measured ink density value determined for the same ink in at least one other inking zone. The measured ink density value for the specific ink in the selected ink zone is rejected as being implausible, and is not used for automatically regulating the ink in the printing press, if the relation between the measured value and the measured value for the same ink in the at least one other inking zone inadmissibly either exceeds or lies below at least one predefined threshold value.

A priority flow rate control valve (4) increases a distribution ratio of pressurized oil to a power steering device (1) of a fork-lift track via a power steering oil passage (9) as a differential pressure between a power steering pressure (PS) in the power steering oil passage (9) and a pilot pressure (LS) decreases. A load signal port (24) which outputs a pressure indicative of a load exerted on the power steering device (1) and the power steering oil passage (9) are connected via two orifices (26A, 26B), and the pilot pressure (LS) pressure is extracted from a point between the two orifices (26A, 26B). By providing a bypass passage (31, 35) which bypasses one of the two orifices (26A, 26B) and a bypass valve (30) which opens and closes the bypass passage (26A, 26B), a response of the priority flow rate control valve (4) can be increased temporarily.

In order to treat solar cells in an electroplating device, they can be inserted into a grid-like or tray-like picking-up device. They are thus mechanically held and electrical contact is made with them via contacts. Instead of individual solar cells, the picking-up devices are moved with a large number of inserted solar cells through the electroplating device for treatment. Electrical contact with the solar cells is in this case made via the contacts and the frame limbs on a projecting angle section together with edge strips of the pick-up. Contact rollers rest on the edge strips and are connected to an electrical power source.

A priority flow rate control valve (4) increases a distribution ratio of pressurized oil to a power steering device (1) of a fork-lift track via a power steering oil passage (9) as a differential pressure between a power steering pressure (PS) in the power steering oil passage (9) and a pilot pressure (LS) decreases. A load signal port (24) which outputs a pressure indicative of a load exerted on the power steering device (1) and the power steering oil passage (9) are connected via two orifices (26A, 26B), and the pilot pressure (LS) pressure is extracted from a point between the two orifices (26A, 26B). By providing a bypass passage (31, 35) which bypasses one of the two orifices (26A, 26B) and a bypass valve (30) which opens and closes the bypass passage (26A, 26B), a response of the priority flow rate control valve (4) can be increased temporarily.

This invention provides a duo-two leading type drum brake device which simplifies a drum brake structure as well as improves a transmission efficiency of a application force from a shoe actuator to brake shoes. A pivot lever 60 has an intermediate portion pivotally supported on the brake shoes 40. A shoe-actuator 20 is positioned adjacent to the first anchors 30, 30 and being disposed between the ends 60a, 50a of the pivot lever 60 and the other brake shoe 50. A strut 70 is positioned between and functionally engaged with the other ends 60b, 50b of the pivot lever 60 and the other brake shoe 50. An application force of the shoe actuator 20 is transmitted to the brake shoe 40 via a pivot section of the pivot lever 70 and transmitted to the other brake shoe 50 directly from the shoe-actuator 20 and indirectly via the strut 70.

In a lash adjuster of a valve gear which employs a serration-shaped thread mechanism, the formation of a tribochemical reactive film is suppressed by using as the materials for its adjuster screw and nut member (or the materials for their thread surfaces) materials that, even if FM oil is used, the friction coefficient will not extremely decrease. The nut member is provided on the underside of an end plate of a lifter body. The adjuster screw is threadedly engaged in a threaded hole of the nut member. The adjuster screw is biased by a return spring. The female threads of the threaded hole and the male threads of the adjuster screw are serration shaped. One or both of the nut member and the adjuster screw, or the pressured thread surfaces of one or both of them, are formed of a material that will not react with oil additives of FM oil to suppress the formation of tribochemical reactive film, thereby stabilizing the operation of the lash adjuster.

This invention provides a duo-two leading type drum brake device which simplifies a drum brake structure as well as improves a transmission efficiency of a application force from a shoe actuator to brake shoes. A pivot lever 60 has an intermediate portion pivotally supported on the brake shoes 40. A shoe-actuator 20 is positioned adjacent to the first anchors 30, 30 and being disposed between the ends 60a, 50a of the pivot lever 60 and the other brake shoe 50. A strut 70 is positioned between and functionally engaged with the other ends 60b, 50b of the pivot lever 60 and the other brake shoe 50. An application force of the shoe actuator 20 is transmitted to the brake shoe 40 via a pivot section of the pivot lever 70 and transmitted to the other brake shoe 50 directly from the shoe-actuator 20 and indirectly via the strut 70.

The present invention belongs to the field of the application of genetic engineering and gene function, and it is directed to a new medical use of the gene encoding the recombinant soluble tumor necrosis factor α receptor (HusTNFR). The present invention made intervention to fulminant hepatic failure in mice by use of the long-acting recombinant human soluble tumor necrosis factor α receptor and the classic animal models of acute and sub-acute hepatic failure. The results showed that the long-acting soluble tumor necrosis factor αreceptor of the present invention has a half-life extended more than 10 times, and it significantly decreased the mortality of model animals and has superior therapeutic effect for the treatment and / or prophylaxis of acute and sub-acute hepatic failure in model animals. These receptors have a noticeable therapeutic effect for the treatment and / or prophylaxis of acute and sub-acute hepatic failure in comparison with the non-long-acting HusTNFR.

A light quantity adjusting device includes a substrate having an optical path aperture, a blade located on the substrate to adjust the quantity of light passing through the optical path aperture, and an electromagnetic driver that drivingly opens and closes the blade. The electromagnetic driver includes a rotor shaft, an exciting coil, and a frame that rotatably bears the rotor shaft. The rotor shaft includes a pointed first shaft end and a cylindrical second shaft end. The frame has a conical bearing recess that supports the first shaft end and a cylindrical bearing hole that supports the second shaft end. The electromagnetic driver is located so that the first shaft end of the rotor shaft is closer to the substrate than the second shaft end. An arm is coupled to the first shaft end of the rotor shaft to transmit an opening and closing driving force to the blade.