The invention relates to the technical field of color plate coating, and discloses a coating process of a multi-color plate. The coating process comprises the following steps of (S1) pretreatment, (S2) roller coating of a primer layer, (S3) roller coating of a middle coating, (S4) roller coating of a finish paint layer, and (S5) final treatment, wherein the coating process of the finish paint layer comprises the steps of (a) coloring for the first time: coating first paint to the surface of a color plate, and then drying; (b) coloring for the second time: coating second paint to the surface ofthe color plate, and then drying; and (c) coloring for many times: coating nth paint to the surface of the color plate, and then drying. The step (S4) relates to a plurality of roller coaters, coating rollers which are used for transferring the paint to the color plate are respectively arranged on each roller coater, the coating rollers comprise coating areas and sunken areas, the coating areas are abutted with the color plate, different coating areas are different from each other, and the sum of the widths of all of the coating areas is equal to the width of the color plate. According to thecoating process, roller coating of different colors is performed in different areas of the color plate by utilizing the plurality of roller coaters, so that the processing of the multi-color plate isrealized, the sense of art and applicability of the color plate are increased, and the diversified customer requirements are met.