The invention discloses a cultivation method for brachymystax lenok fry. The cultivation method includes the steps of A, artificial incubation; B, fry opening feeding; C, transferring out of an incubation tank for cultivation, and stocking at reasonable density; D, pool dividing domestication, wherein palatable bait is selected, food domestication control is conducted, and meanwhile scientific daily management and disease prevention are conducted. According to the biological characteristics of brachymystax lenok, total artificial regulation is conducted on the aspects of water temperature, illumination, dissolved oxygen and the like, the advantages that the physiques of the fry are healthy, strong and balanced, the bait utilization rate is high, environmental tolerance is high, and disease resistance is high are achieved by means of food intake regulation and standard management, and the fertilized ovum hatching rate of the brachymystax lenok and the growth rate and survival rate of offspring fishes are greatly increased. The offspring fishes are healthy, strong and balanced, high environmental tolerance and disease resistance are achieved, and occurrence of malformation is greatly reduced. The method is simple, high in operability, good in practical applicability and completely suitable for large-scale production of the fry, and is used for species resource protection and natural population restoration of the brachymystax lenok accordingly.