The invention relates to the technical field of automatic assembly, in particular to a multi-shaft tightening torque-changing and position-changing mechanism which comprises a mounting base, a position-changing drive speed reducer, a position-changing drive motor, a position-changing shaft assembly, a position-changing drive gear mechanism, position-changing shaft connecting base plates, a mechanism torque measuring buffer shaft assembly, a toque-changing plate, a torque-changing mechanism drive unit, a torque-changing drive gear mechanism, sliding limiting blocks, tightening shaft mounting seats, tightening shafts, a mechanism torque measuring buffer press rod and a mechanism torque measuring buffer head. According to the mechanism, the multiple tightening shafts can tighten circumferentially-distributed screws, the tightening shafts are precisely controlled within a certain range to move in the radial direction to any radius, tightening of the screws of different circumferential distribution radii is achieved, and compatibility and flexibility of tightening equipment are improved; and when the screws are tightened, the screw tightening depth can be monitored in real time, and thetightening quality can be improved better by combining angle and torque monitoring of the tightening shafts.