The invention discloses cassava cultivation special-purpose organic compound fertilizer. The cassava cultivation special-purpose organic compound fertilizer comprises, by dry weight, 20-22 parts of peanut vine fine sections, 17-19 parts of peanut shell crude powder, 4.5-5.5 parts of peanut bran crude powder, 11-13 parts of sugar refinery mud crude powder, 7-8 parts of cow dung, 7-8 parts of pig manure, 4.5-5.5 parts of chicken manure, 0.5-1.5 parts of a water-retaining agent, 0.05-0.15 parts of tuba root powder, 0.007-0.015 parts of microbe inocula, 11.5-12 parts of urea, 15-16 parts of calcium superphosphate, 7-8 parts of potassium chloride and 0.8-1.2 parts of slaked lime. The cassava cultivation special-purpose organic compound fertilizer has a reasonable formula and comprehensive and abundant nutrition and provides full nutrients for cassava growth. The preparation method has simple processes, a low cost and a wide raw material source and realizes comprehensive utilization of wastes. The cassava cultivation special-purpose organic compound fertilizer reduces environmental pollution, improves soil organic matter content, improves a cassava yield and cassava quality, reduces a fertilizer use amount, improves an ecological environment and has good economic benefits, social benefits and ecological benefits.