The invention discloses a solubleand efficient
recombinant expression methodfor
fibroblast growth factor protein. In the method, as for an
escherichia coli strain of a carrier containing coding-recombinant
fibroblast growth factor family
protein, expression of intracellularactive
protein is promoted by adding a certain dosage of
monosaccharide during induction.The
fibroblast growth factor family protein comprises FGF1, FGF2, FGF4, FGF7, FGF8, FGF9, FGF11, FGF15, FGF18, FGF21, FGF23 and mutants of the
fibroblast growth factor family protein. As for the process that the certain dosage of
monosaccharide is added during induction, the
monosaccharide is supplemented into before an inductive agent is added, or the monosaccharide is supplemented into while an inductive agent is added, or the monosaccharide is supplemented into after the inductive agent is added. The technology prejudice that expression of lac and araoperons is inhibited by glucose in
escherichia colirecombinant is overcome inthe technical field, and the method capable of efficiently promoting expression of the
fibroblast growth factor protein in
escherichia coli is applied.