The invention discloses a
stomach cancer prognostic marker screening and classifying method based on a
gene expression profile. The
stomach cancer prognostic marker screening and classifying method comprises that a
gene the expression of which is changed is screened out from data of the
gene expression profile Cox proportional
hazard model analysis is established aiming at the screened gene, a gene which has
statistical significance is selected as a seed gene, a maximum likelihood model is constructed by means of clinical follow-up
information data of the patient to screen out prognosis
key genes, then the risk coefficient of each prognosis key gene in the patient is calculated, classification and statistic
verification are carried out in dependence on the number of prognosis
key genes of the patient, and an optimal classification mode is selected. According to the invention, dimensionality of high-dimension miscellaneous
gene expression profile data can be effectively reduced, several
key genes which can be applied to clinical detection easily are screened out from tens of thousands of genes, survival and the
recurrence risk of the patient are predicted by means of the expression case of the several key genes.