The invention relates to a 2PRU (Pseudo-Random Upstream) and CRS (Central Reservation System) spatial parallel robot mechanism. The 2PRU and CRS spatial parallel robot mechanism is formed by a motion platform, a fixed platform and three branch chains, wherein the three branch chains are used for connecting the motion platform and the fixed platform, the first branch chain and the second branch chain in the three branch chains are the same in structure and are respectively formed by a universal joint pair, a rotating pair, a moving pair and connecting rods among the universal joint pair, the rotating pair and the moving pair from top to bottom, and the third branch chain in the three branch chains is formed by a ball pair, a rotating pair, a cylinder pair and connecting rods among the ball pair, the rotating pair and the cylinder pair from top to bottom. According to the 2PRU and CRS spatial parallel robot mechanism disclosed by the invention, three movable motion output can be realized, the mechanism is simple, processing and manufacturing are easy, a kinematic model is simple, kinematic calibration and control can be easier, meanwhile, joints of the mechanism are less, and the structure rigidity is increased.