The invention discloses a
cancer prediction model construction method based on a causal network and adaptive
feature selection, and the construction process comprises the steps: 1) obtaining multi-
omics data, and generating an
omics feature matrix through similarity network iterative fusion, chi-square test dimension reduction and
diffusion enhancement; 2) introducing a causal
diffusion Do-calculus
algorithm to construct a
gene causal
consensus network, constructing a sample specific network in combination with
local regression residual analysis, and extracting topological features to obtain a network
feature matrix; 3) calculating a
modal weight based on balance accuracy, and performing weighted splicing to generate an integrated multi-
modal feature; and 4) inputting the integrated multi-
modal features into a full connection layer embedded with a feature gating mechanism and sparse
group Lasso regularization, obtaining a
cancer prediction model through end-to-end training, and screening core markers. The problems that an existing prediction model is poor in multi-
omics data integration effect, lacks a causal mechanism and is difficult to explain deep nonlinear interaction of genes are solved, and the precision and generalization ability of the
cancer prediction model are improved.