The invention relates to the communication field, and discloses a method and device for adjusting distribution positions of frequency-domain resources, so as to ensure signal quality of a terminal when an uplink transmission is performed based on discontinuous frequency-domain resources. The method comprises the following steps: in a case that the uplink transmission is performed by using discontinuous frequency-domain resources in an LTE-A (long term evolution-advanced) system, a terminal can obtain a corresponding largest frequency-domain interval according to a network-environment-based MPR (multiple protocol router) threshold value; and then based on the largest frequency-domain interval, the distribution positions of discontinuous frequency-domain resources used by the terminal are adjusted, so as to ensure the interval between each frequency-domain resource not to exceed the determined largest frequency-domain interval. Therefore, when signals are transmitted on the adjusted discontinuous frequency-domain resources, out-of-band emission due to inter-modulation (IMD) generated between each frequency-domain resource is effectively reduced, and thus the transmission quality of uplink signals are ensured, so that adverse effects to system coexistence and system performance are avoided while gain for user performance brought by the discontinuous frequency-domain transmission is fully used.