The invention provides a prediction method for the full-order permeability tensor of a porous medium. The prediction method comprises the steps that firstly, a control model of flowing of fluid in the porous medium is constructed, and the porous medium is divided into a plurality of staggered grids; secondly, the fluid flows in the porous medium in the first direction, and the control model is solved through the finite difference method so that local velocity components uli,j and vli,j of different points in the grids can be determined; thirdly, according to the local velocity components u1i,j and v1i,j, the first darcy velocities u1D and v1D of the fluid are determined through the piecewise quadratic parabola numerical integration method; fourthly, the fluid flows in the porous medium in the second direction perpendicular to the first direction, and the control model is solved through the finite difference method so that local velocity components u2i,j and v2i,j of different points in the grids can be determined; fifthly, according to the local velocity components u2i,j and v2i,j, the second darcy velocities u2D and v2D of the fluid are determined through the piecewise quadratic parabola numerical integration method; sixthly, the full-order permeability tensor of the fluid in the porous medium is determined according to the first darcy velocities and the second darcy velocities.