The invention discloses a coal and gas co-mining three-dimensional physical simulation comprehensive experiment system, and belongs to the technical field of coal and gas safe co-mining. The system comprises a box, a hydraulic mining unit, a hydraulic loading unit, a ventilation roadway unit, a gas injection control unit, and a test unit. The first surface and third surface, which is opposite to the first surface, of the box are both provided with a gas testing hole. The second surface of the box is provided with an air inlet hole and an air return hole. The fourth surface of the box is provided with a wire outlet hole. The hydraulic mining unit comprises parallelly arranged hydraulic cylinders and support steel bars, and two hydraulic cylinders and the bottom of the box connect and support one steel bar. The hydraulic loading unit comprises a loading frame, which is arranged on the guide rails of the box. The guide rails are arranged on two sides of the box. The ventilation roadway comprises a roadway and a ventilating machine. A high pressure steel bottle in the gas injection control unit is communicated with a multi-way air distribution cabinet through an air distribution pipe, the air distribution pipe is communicated with a sub-pipeline; and the test unit comprises a gas testing unit, a stress testing unit, and a slight shock testing unit.