The invention provides a method for detecting reliability of data communication of synchronous serial communication, relates to the technical field of communication detection, and is used for solving the technical problem of the reliability of the data communication of synchronous serial communication. A data frame format used in the method comprises a two-bit header, a two-bit address choice, an eight-bit communication data, a one-bit feature bit, a two-bit flag bit and a one-bit mark bit. The method comprises the following steps: 1) sending the front 13 bits by a data communication initiator according to the format, monitoring a feedback data of a receiving terminal at real time, and comparing; 2) if the result is correct, sending '00'on the two-bit flag bit, and if not, sending '11'; and 3) if a receiver has any fault bit in detection process, abandoning the data and requiring for resending through the last one-bit mark bit, and if any bit is correct, transferring the last one-bit mark bit '0'and receiving the next frame data. The method provided by the invention has the advantages that the operation is simple, the comparison is reliable and the treatment is timely.