The invention discloses an intelligent highway mist zone guiding system and belongs to the technical field of road traffic safety. The intelligent highway mist zone guiding system comprises a front end node controller, a variable message sign, a speed limit sign, a vehicle flowrate detector, a node controller, visibility detection controllers, cameras, guiding node controllers, vehicle detectors, alarm devices and induction lamps. According to the intelligent highway mist zone guiding system, expensive visibility detectors are replaced with the cameras which are arranged at a certain interval in an agglomerate fog-prone zone, ultrahigh frequency radio frequency identification technologies are used for detecting a vehicle flowrate and vehicle positions, vehicles are prompted to keep a low speed and a safe interval via an acousto-optic alarm mode when vehicle-to-vehicle distance is too small, traffic accidents can be effectively prevented, Zigbee short range wireless information transmission technologies are adopted, workload of on-site system construction can be reduced, and system cost can be lowered. Via use of the intelligent highway mist zone guiding system, safety of vehicles running in conditions of low visibility weather, and traffic accidents can be effectively prevented.