33results about "Sulfo/sulfonyldioxy group formation/introduction" patented technology

A process and equipment assembly for reacting a substituent precursor with a cyclodextrin starting material to provide a raw product comprising a cyclodextrin derivative and 1% or less of an initial amount of the substituent precursor is provided. The process of the present invention provides cyclodextrin derivatives in substantially shorter time and with fewer side products than previous processes that utilize substantially the same starting materials.

The present invention relates to a gas phase SO3 film-scraping sulfonating technology which belongs to the technical field of production technology which prepares anionic surfactant by using gas phase SO3 film-scraping sulfonating liquid organic materials. The invention is carried out according to the following steps: A: liquid SO3 is vaporized to gas phase SO3, the gas phase SO3 is sucked in a mixer shaft through a turbo-blower, the gas phase SO3 is mixed with inert gases recycled in a sulfonating reactor to reaction gas with the volume concentration being 0.1 to 10 percent, and then the reaction gas goes into a reaction cylinder body through reaction gas distribution holes on the upper part of the scraping plate shaft; B: the organic materials go into the sulfonating reactor and downwards flow along the inner wall of the reaction cylinder body, a scraping plate is rotated along with the mixer shaft under the action of a transmission system, the organic materials are continuously suffered with film scaping-spread coating-film scaping in the inner wall of the reaction cylinder body, the organic material are alternately updated and uniformly coated on the inner wall of the reaction cylinder body, and the organic materials are completely contacted and reacted with the reaction gas which goes from the reaction gas distribution holes to form reaction products. The design of the technology is reasonable, and the invention can be suitable for sulfonating or sulphating materials with various viscosities.

The invention discloses a preparation method of a heparinoid, comprising: taking chondroitin sulfate as a raw material, and obtaining heparinoid after sulfonation reaction; the solvent used in the sulfonation reaction is formamide, and the sulfonating agent used is free trisodium Sulfur oxide, oleum or pyridinic sulfur trioxide. The preparation method of heparinoid according to the present invention has simple synthesis process, easy control of production operation, no special requirements for production equipment, stable molecular weight range of the product, control of physical and chemical indicators within the range of quality standards, high product yield, and is suitable for large-scale industrialization Production.

The invention discloses a method for detecting process and end point of sulfur trioxide sulfonation. The method comprises the following steps that: (1) a conductance-detecting electrode is inserted into reactant subjected to sulfonation; the conductance of the reactant is detected and displayed in real time; the conductance of the reactant decreases along with the process of sulfonation; and sulfur dioxide gas is adopted as a sulfonating agent in the sulfonation; and (2) when the conductance of the reactant is detected to decrease to zero, the sulfonation reaches the end for sure. The method has the advantages of tracking the process of the sulfonation in real time through the conductance change of sulfonation solution, accurately judging the end point of the sulfonation, reminding operators in real time, ensuring that reaction cannot exceed the end point, leaving out the trouble of chemical sampling detection and avoiding the phenomenon that the chemical sampling detection is not timely and accurate enough in results.

The invention relates to a wiped-film sulfonator, belonging to the manufacturing technical field for a reaction device for producing an anion active agent through sulphonation or sulphation of gas SO3. The device comprises an orthostatic reaction cylinder body (8), a stirring shaft (10) with a scraping plate (9) arranged in the orthostatic reaction cylinder body (8), a lower tube plate (11) and an upper plate(5) with a sealed tube plate (4) which are arranged at the two ends of the orthostatic reaction cylinder body; an upper head (2) with a SO3 gas inlet (1) which is arranged at the upper part of the sealed tube plate, a lower head (12) with a reactant outlet (16) arranged at the lower part of the lower tube plate (11), a motor (18) with a reducer (17) which is connected with the stirring shaft (10) and fixed at the upper head (2) or the lower head (12) and 1-3 section cooling jackets (14) with a cooling water inlet (13) and a cooling water outlet (15) which is arranged at the periphery of the orthostatic reaction cylinder body (8), etc. The general structure is designed reasonably, the operation is flexible, the manufacture is easy and the investment is small.

An azasteroid mimic or an intermediate for the preparation of an azasteroid and azasteroid mimic is formed via an oxocycloalkenyl isoxazolium anhydrobase and its dimer. The dimer can be used to form mono- and dihydrazones, which can be an azasteroid mimic or an intermediate for the preparation of an azasteroid and azasteroid mimic. A method of preparation of the dimer and the azasteroid mimic or an intermediate for the preparation of an azasteroid and azasteroid mimic occurs with hydrazonation and, optionally, a subsequent dehydrazonation. The dimer can be converted by inserting a nitrogen atom into the six membered ring of to a C-17 position cyclohexenone moiety of the dimer to yield a reduced tetrazolo[1,5-a]azepin-8-yl group. A subsequent hydrozone formation at a benzylic ketone can be carried out to generate an azasteroid mimic with a (triazol-4-yl)imino substituent. Monohydrazones can be converted to their thione equivalents.