The invention provides a 780 MPa hot-rolled high-strength steel with high hole expansion ratio and a manufacturing method thereof. The 780 MPa hot-rolled high-strength steel with high hole expansion ratio comprises the following chemical components in percentage by mass: more than or equal to 0.03 percent and less than or equal to 0.07 percent of C, less than or equal to 0.2 percent of Si, more than or equal to 1.0 percent and less than or equal to 2.0 percent of Mn, less than or equal to 0.02 percent of P, less than or equal to 0.005 percent of S, more than or equal to 0.02 percent and less than or equal to 0.05 percent of Al, less than or equal to 0.005 percent of N, more than or equal to 0.08 percent and less than or equal to 0.20 percent of Ti, more than or equal to 0.15 percent and less than or equal to 0.25 percent of Mo, less than or equal to 0.003 percent of O and the balance of Fe and inevitable impurity elements, wherein Ti/Mo is more than or equal to 0.25 and less than or equal to 1.5, and (Ti-3.42N)/4+Mo/8 is more than or equal to 0.03 percent and less than or equal to 0.07 percent. The 780 MPa hot-rolled high-strength steel with high hole expansion ratio is obtained through smelting, casting, high-temperature heating, hot rolling and reeling processes, and is more than or equal to 750 MPa in yield strength, more than or equal to 780 MPa in tensile strength, more than or equal to 20 percent in extensibility, more than or equal to 70 percent in hole expansion ratio when the thickness is 3-6 mm.