The invention discloses a device for quickly guiding instruction transmission of an unmanned aerial vehicle based on a manned aerial vehicle, and belongs to the field of aviation electronic automation. The device comprises a touch guide module, a voice guide module, an instruction classification module, an instruction decoder, an integrated task processor and an execution mechanism; the device performs fast command and guide, so that the convenience and the flexibility of operation and control of an aviator can be greatly improved under a high decision pressure, the instruction input efficiency is improved, and the advantage opportunity of defense is obtained; the device gets rid of the tedious operations of the target interception mode of the traditional manned aerial vehicle to guide the unmanned aerial vehicle, simplifies the operation flows of the aviator, realizes the fast transmission of multiple unmanned aerial vehicle guide instruction based on a manned aerial vehicle cabin, and guides the unmanned aerial vehicle to lock a target and accomplish tasks. In a rapidly changing task environment situation, the operation time is shortened, the initiative is fought for, the misoperations of the manual operations of the aviator under high pressure can be avoided, the risks are controlled, the pressure is relieved, and the efficiency of accomplishing the tasks is improved.