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34results about How to "Inconvenient to store" patented technology

Method for preparing dapoxetine hydrochloride

ActiveCN106883133AAvoid splittingSolve the serious problem of lossOrganic compound preparationAmino-hyroxy compound preparation3-amino-3-phenylpropionic acidBorohydride
The invention discloses a method for preparing dapoxetine hydrochloride. The method comprises the following steps: subjecting (s)-3-amino-3-phenylpropionic acid or an ester thereof to a reduction reaction in a reduction system prepared from a hydroborate and a boron trifluoride complex, so as to obtain an intermediate 1, i.e. (s)-3-amino-3-phenylpropanol; subjecting the (s) intermediate 1 to an Eschweiler-Clark reaction with formic acid and formaldehyde, so as to obtain an intermediate 2; subjecting the intermediate 2 to a Williamson ether forming reaction with 1-fluoronaphthalene, so as to obtain a free alkali, i.e. (s)-N,N-dimethyl-3-(1-naphthyloxy)phenyl propyl amine; subjecting the free alkali to a salt forming reaction with alcohol-acyl chloride or a chloride thereof, a hydrochloric acid organic solution or hydrochloric acid gas, thereby obtaining dapoxetine hydrochloride. According to the method, the synthesis route is low in production cost, the reaction conditions are mild, all the materials are readily available, the raw materials are low in toxicity, the reaction is simple in operation and high in safety, and the product is high in purity and yield and is environmentally friendly, so that the method is applicable to industrial large-scale production.
Owner:SPRINGPHARMA CO LTD

Antibacterial handmade white tea soap and production method thereof

InactiveCN110835587AAvoid damageGood for whitening, anti-oxidation, and moisturizing the skinSoap detergents with organic compounding agentsDetergent compounding agentsBiotechnologyLanolin
The invention discloses an antibacterial handmade white tea soap. The antibacterial handmade white tea soap comprises, by mass, 40-50 parts of sodium carbonate, 10-20 parts of amino acids, 1-10 partsof palm oil, 1-10 parts of perilla seed oil, 1-10 parts of olive oil, 1-5 parts of lanolin, 1-3 parts of white tea extract, 0.5-2 parts of EGCG nano-liposome, 0.1-0.5 part of compound vitamins, 0.1-0.5 part of an antibacterial agent, 0.1-0.3 part of sodium hyaluronate, 0.1-0.3 part of trehalose, 0.1-0.3 part of transdermal oligopeptide, 0.1-0.3 part of propolis and 0.1-0.3 part of plant essentialoil. A production method of the soap comprises the following steps: taking and dissolving sodium carbonate in distilled water; sequentially adding the amino acids, palm oil, olive oil, perilla seed oil and lanolin into a sodium carbonate solution, and carrying out a saponification reaction; adding the lanolin, white tea extract, EGCG nano lipidosome, compound vitamins, the antibacterial agent, sodium hyaluronate, trehalose, transdermal oligopeptide and propolis, and performing stirring for a reaction; and discharging the obtained material, pouring the material into a mold, solidifying the material, demolding the solidified material, and trimming the demolded material to obtain the antibacterial handmade white tea soap. The antibacterial handmade white tea soap has the advantages of long preservation time, high soap body stability, moistening and sterilizing effects, good hand feeling, resistance to oxidation, and easiness in absorption.
Owner:茗汲(浙江)生物科技有限公司

A kind of preparation method of dapoxetine hydrochloride

ActiveCN106883133BAvoid splittingSolve the serious problem of lossOrganic compound preparationAmino-hyroxy compound preparation3-amino-3-phenylpropionic acidBorohydride
The invention discloses a method for preparing dapoxetine hydrochloride. The method comprises the following steps: subjecting (s)-3-amino-3-phenylpropionic acid or an ester thereof to a reduction reaction in a reduction system prepared from a hydroborate and a boron trifluoride complex, so as to obtain an intermediate 1, i.e. (s)-3-amino-3-phenylpropanol; subjecting the (s) intermediate 1 to an Eschweiler-Clark reaction with formic acid and formaldehyde, so as to obtain an intermediate 2; subjecting the intermediate 2 to a Williamson ether forming reaction with 1-fluoronaphthalene, so as to obtain a free alkali, i.e. (s)-N,N-dimethyl-3-(1-naphthyloxy)phenyl propyl amine; subjecting the free alkali to a salt forming reaction with alcohol-acyl chloride or a chloride thereof, a hydrochloric acid organic solution or hydrochloric acid gas, thereby obtaining dapoxetine hydrochloride. According to the method, the synthesis route is low in production cost, the reaction conditions are mild, all the materials are readily available, the raw materials are low in toxicity, the reaction is simple in operation and high in safety, and the product is high in purity and yield and is environmentally friendly, so that the method is applicable to industrial large-scale production.
Owner:SPRINGPHARMA CO LTD
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