The present invention relates to compositions of and methods for producing timed or retarded release formulations that contain green coffee extract, and optionally vinpocetine, L-camitine, of amylase inhibitor, niacin, Vitamin B3 (niacinamide), vitamin B6 (pyridoxine hydrocholoride), vitamin B12 (cyanocobaolamin), vitamin B5 (pantothenic acid), inositol, phosphorus, iodine, and chromium and/or their dietary and nutraceutically acceptable salts of the same and/or hydrates of the active substance that provide a timed or retarded release formulation of the active substance.