The present application relates to the technical field of biomedical materials and scar treatment, and particularly relates to a flexible self-powered conductive hydrogel microneedle dressing and a preparation method and application thereof, the dressing is an integrated wearable structure, comprising a microneedle layer, a conductive hydrogel layer, an
air cell layer and an encapsulation layer, the conductive hydrogel layer serves as an
ion conducting layer of a flexible
zinc-
air cell cathode, and a
zinc anode is connected to a conductive network at the edge of the conductive hydrogel through a flexible lead; the conductive hydrogel is prepared by using
acrylic acid-2-methoxyethyl ester, etc., and a dry-wet separation activated
zinc-
air cell is integrated to realize self-power supply; the present application does not need an external power supply, has good portability, can be well attached to the
skin, regulates the scar repair process through continuous and accurate electric stimulation, promotes the migration of fibroblasts, regulates collagen synthesis, inhibits
inflammation and
fibrosis, has excellent
biocompatibility, simplifies the operation process, reduces the medical cost, and is suitable for the treatment of
hypertrophic scars and keloids.