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39 results about "Adenine derivatives" patented technology
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Adenine derivatives, in particular the scaffold bearing the acyclic nucleoside phosphonates (ANPS), possess significant antiviral and cytostatic activity. Till now, several effective adenine derivatives have been marketed for the treatment of HIV, HBV, CMV and other virus-infected diseases.
Nucleotide derivative and DNA microarray
ActiveUS7414117B2Easy to prepareSugar derivativesMicrobiological testing/measurementCytosineDNA microarray
A novel nucleotide derivative, in case of existing as a member of a single-stranded sequence, undergoing a change in the fluorescent signal intendity depending on the corresponding base type in the partner strand with which the single-stranded sequence is hybridized, and which is a thymin / uracil derivative (1) emitting light most intensely when a confronting base in the partner strand with which the single-stranded nucleotide sequence is hybridized is adenine; a cytosine derivative (2) emitting light most intensely when the confronting base is guanine; an adenine derivative (3) emitting light most intensely when the confronting base is cytosine; a guanine derivative (4) emitting light most intensely when the confronting base is cytosine or thymine / uracil; and an adrnine derivative (5) emitting light most intensely when the confronting base is thymine / uracil / .
Owner:SAITO ISAO +1
Adenine derivatives
The present invention relates to compounds of formula (I):wherein R1 is C1-6alkylamino, or C1-6alkoxy; R2 is a group having the structure:n is an integer having a value of 1 to 6; Het is a 6-membered saturated heterocycle containing one nitrogen atom wherein Het is attached to the —(CH2)n— moiety at any carbon atom of the heterocycle; R3 is hydrogen, C1-8alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.
Owner:GLAXO SMITHKLINE LLC
Adenine derivative as inhibitors of HSP90 for the treatment of cancer
Owner:CHROMA THERAPEUTICS
Adenine derivatives
Compounds of formula (I):wherein R1 is C1-6alkylamino, or C1-6alkoxy; R2 is a group having the structure:n is an integer having a value of 1 to 6; Het is a 6-membered saturated heterocycle containing one nitrogen atom wherein Het is attached to the —(CH2)n— moiety at any carbon atom of the heterocycle; R3 is hydrogen, C1-8alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.
Owner:GLAXO SMITHKLINE LLC
Phosphonate prodrug of adenine derivative and medical application of phosphonate prodrug
ActiveCN106543227AOrganic active ingredientsGroup 5/15 element organic compoundsAdenine derivativesViral infectious disease
The invention relates to a phosphonate prodrug of an adenine derivative and medical application of the phosphonate prodrug. Specifically, the invention relates to a compound shown in a general formula (I) or an optical isomer, or a pharmaceutical salt, or a hydrate or a solvate of the compound, and application of the compound or the optical isomer, or the pharmaceutical salt, or the hydrate or the solvate of the compound to preparation of medicines for curing virus infective diseases, especially hepatitis B (HBV) and acquired immune deficiency syndrome (HIV), wherein the definitions of all substituents in the general formula (I) are the same as the definitions in the specification.
Owner:HANGZHOU HEZE PHARMA TECH +1
Adenine derivatives as protein kinase inhibitors
The present invention relates to a compound suitable for use as a kinase inhibitor according to general formula (I) [compound (C), herein after], or the N- oxide, pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or stereoisomer thereof, formula (I) wherein A, R1, R2, R3, R3', R4, R4', X, Y, Z, T are as defined in the claims. The invention further relates to an in vitro methodof inhibiting protein kinase activity which comprises contacting a protein kinase with a compound of formula (I), or the N-oxide, pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or stereoisomer thereof. The invention further relates to the compounds of formula (I) per se, as well as to their use as a medicament, and for use or in a method of treatment of a disease mediatedby a protein kinase selected from cancer, inflammatory disorders, cardiovascular diseases, viral induced diseases, circulatory diseases, fibro-proliferative diseases and pain sensitization disorders.
Owner:BCI PHARMA
N6-substituted adenosine derivatives and n6-substituted adenine derivatives and uses thereof
The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.
Owner:INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
Novel adenine derivatives
Compounds of formula (I):wherein R1 is C1-6alkylamino, or C1-6alkoxy; R2 is a group having the structure:n is an integer having a value of 1 to 6; Het is a 6-membered saturated heterocycle containing one nitrogen atom wherein Het is attached to the —(CH2)n— moiety at any carbon atom of the heterocycle; R3 is hydrogen, C1-8alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.
Owner:GLAXO SMITHKLINE LLC
Adenine derivative and inclusion compound thereof
ActiveCN102977146AStrong antiviral activityImprove securityOrganic active ingredientsGroup 5/15 element organic compoundsAdenine derivativesPurine
The invention discloses the technical field of medicines and particularly discloses a new prodrug, namely (R)-9-(2-(phosphonyl methoxyl)propenyl) adenine, a cyclodextrin inclusion compound of the prodrug and a non-toxic and pharmaceutically acceptable salt of the prodrug. The prodrug disclosed by the invention can be metabolized into PMPA in vivo, and has the bioavailability of about 39%, and the bioavailability of the prodrug is better than that of tenofovir disoproxil fumarate (Bis-(POC)-PMPA); and the prodrug has more excellent antiviral activity and better safety compared with the tenofovir disoproxil fumarate.
Owner:STAR LAKE BIOSCI CO INC ZHAOQING GUANGDONG
Calix[4]arene adenine derivative-oxidized graphene compound, preparation method and applications thereof
InactiveCN105823764ASimple manufacturing processEase of industrial production in large quantitiesFluorescence/phosphorescencePhotochemistryParticle suspension
The invention relates to a calix[4]arene adenine derivative-oxidized graphene compound, a preparation method and applications thereof. The compound is formed by connecting oxidized graphene and calix[4]arene adenine derivatives through amido bonds. The preparation method comprises the following steps: (1) subjecting oxidized graphene to chloroformylation; (2) dissolving excess calix[4]arene adenine derivatives by an organic solvent, adding chloroformylated oxidized graphene powder, stirring for 6 to 96 hours at a room temperature to obtain a black particle suspension liquid, carrying out centrifugal separation, carrying out saturated salt water washing, adding distilled water, carrying out centrifugal separation, and drying to obtain black powder namely the calix[4]arene adenine derivative-oxidized graphene compound, which can be used to recognize, combine, and stabilize cancer gene promoter region G-quadrome. Compared with the prior art, the preparation technology is simple and easy to perform, and a novel method is provided to detect G-quadrome through biological macro-cycle molecules.
![Calix[4]arene adenine derivative-oxidized graphene compound, preparation method and applications thereof](https://images-eureka.patsnap.com/patent_img/80827070-760f-47a7-bf49-b957909f97d2/HDA0000943785520000011.PNG "Calix[4]arene adenine derivative-oxidized graphene compound, preparation method and applications thereof")
![Calix[4]arene adenine derivative-oxidized graphene compound, preparation method and applications thereof](https://images-eureka.patsnap.com/patent_img/80827070-760f-47a7-bf49-b957909f97d2/HDA0000943785520000012.PNG "Calix[4]arene adenine derivative-oxidized graphene compound, preparation method and applications thereof")
![Calix[4]arene adenine derivative-oxidized graphene compound, preparation method and applications thereof](https://images-eureka.patsnap.com/patent_img/80827070-760f-47a7-bf49-b957909f97d2/HDA0000943785520000021.PNG "Calix[4]arene adenine derivative-oxidized graphene compound, preparation method and applications thereof")
Owner:TONGJI UNIV
Adenine kind derivative and its synthesis method
ActiveCN1752087AImprove biological activityIncreased cytokinin activityOrganic chemistryAntipyreticAdenine derivativesSynthesis methods
An adenine derivative series is prepared from bromobenze with borate radical through Dimroth rearranging reaction. Its advantage is high activity to suppress proinflammatory factor (tumor necrosis factor alpha) and splitting cell.
Owner:SHANGHAI HETENG FINE CHEM
Adenine derivative as inhibitors of HSP90 for the treatment of cancer
InactiveUS20100035901A1Enhanced and prolonged activityBiocideCarbamic acid derivatives preparationAdenine derivativesHSP90 Heat-Shock Proteins
The invention provides a compound which is (a) an amino acid derivative of formula (I) or a tautomer thereof, or (b) a pharmaceutically acceptable salt, N-oxide, hydrate or solvate thereof: wherein R1, R2, L1, Het, A, x, y and W are as defined herein. The compounds are useful in the treatment of diseases mediated by HSP90.
Owner:CHROMA THERAPEUTICS
Adenine derivatives and their use as uv-photoprotective agents
ActiveUS20180298004A1Improve water-binding capacityIncrease capacityBiocideCosmetic preparationsAdenine derivativesPurine
Adenine derivatives substituted at the C2, N6, and N9 purine positions having antisenescent and combined photoprotective UVA / UVB effects. These substances are particularly suitable as anti-senescent and UV-photoprotective component in cosmetic preparations, plant protection preparations and in preparations for the treatment / application of tissue cultures
Owner:UNIV PALACKEHO V OLOMOUCI
Nucleotide derivative and DNA microarray
A novel nucleotide derivative, in case of existing as a member of a single-stranded sequence, undergoing a change in the fluorescent signal intensity depending on the corresponding base type in the partner strand with which the single-stranded sequence is hybridized, and which is (1) a thymine / uracil derivative emitting light most intensely when a confronting base in the partner strand with which the single-stranded nucleotide sequence is hybridized is adenine; (2) a cytosine derivative emitting light most intensely when the confronting base is guanine; (3) an adenine derivative emitting light most intensely when the confronting base is cytosine; and, (4) a guanine derivative emitting light most intensely when the confronting base is cytosine or thymine / uracil.
Owner:ISAO SAITO +1
Assays for s-adenosylmethionine-dependent methyltransferases
InactiveUS20100291605A1Improve purification effectLow absorbanceMicrobiological testing/measurementBiological material analysisS-Adenosyl-l-methionineChemical reaction
Disclosed are novel methyltransferase assay methods, comprising: including, in a reaction mixture for a methyltransferase activity, a purified or recombinant adenosine nucleosidase activity that catalyses release of an adenine or adenine derivative moiety from a transmethylation product, and a purified or recombinant adenine deaminase activity that catalyses deamination of the released moiety to hypoxanthine or respective derivative and ammonia, wherein the methyltransferase activity is rate-limiting; and determining the methyltransferase activity by spectrophotometric or chromatographic monitoring of the coupled deamination reaction products, or of subsequent enzymatic or chemical reactions coupled thereto. Coupled oxidation of the hypoxanthine to uric acid and hydrogen peroxide is optionally affected using purified or recombinant xanthine oxidase, wherein the methyltransferase activity is rate-limiting, and wherein determining the methyltransferase activity comprises monitoring of the coupled oxidation reaction. Variations are disclosed comprises monitoring of reaction products (e.g., to detect NH3, Hypoxanthine, H2O2, and Uric Acid).
Owner:WASHINGTON STATE UNIV RES FOUND INC
Nucleotide derivative and DNA microarray
InactiveUS7323555B2Easy to prepareSugar derivativesMicrobiological testing/measurementNucleotideFluorescence
A novel nucleotide derivative, in case of existing as a member of a single-stranded sequence, undergoing a change in the fluorescent signal intensity depending on the corresponding base type in the partner strand with which the single-stranded sequence is hybridized, and which is (1) a thymine / uracil derivative emitting light most intensely when a confronting base in the partner strand with which the single-stranded nucleotide sequence is hybridized is adenine; (2) a cytosine derivative emitting light most intensely when the confronting base is guanine; (3) an adenine derivative emitting light most intensely when the confronting base is cytosine; and, (4) a guanine derivative emitting light most intensely when the confronting base is cytosine or thymine / uracil.
Owner:ISAO SAITO +1
Nucleotide derivative and DNA microarray
ActiveUS20050059037A1Easy to prepareSimple and reliable determinationSugar derivativesMicrobiological testing/measurementNucleotideFluorescence
A novel nucleotide derivative, in case of existing as a member of a single-stranded sequence, undergoing a change in the fluorescent signal intensity depending on the corresponding base type in the partner strand with which the single-stranded sequence is hybridized, and which is a thymine / uracil derivative (1) emitting light most intensely when a confronting base in the partner strand with which the single-stranded nucleotide sequence is hybridized is adenine; a cytosine derivative (2) emitting light most intensely when the confronting base is guanine; an adenine derivative (3) emitting light most intensely when the confronting base is cytosine; a guanine derivative (4) emitting light most intensely when the confronting base is cytosine or thymine / uracil; and an adenine derivative (5) emitting light most intensely when the confronting base is thymine / uracil.
Owner:SAITO ISAO +1
Nucleotide derivatives and DNA microarray
InactiveCN1732181AEasy to makeSure easy sureSugar derivativesMicrobiological testing/measurementFluorescenceNucleotide
A novel nucleotide derivative showing a change in the fluorescent signal intensity depending on the corresponding base species of the counterpart chain of hybridization. And occurring as a member of a single-strand nucleotide sequence, where the corresponding base of the counterpart chain of the hybridization of the single-strand sequence is as followed:(1) which is a thymine / uracil derivative showing the most intense light emission in the case where the corresponding base is adenine; (2) which is a cytosine derivative showing the most intense light emission in the case where the corresponding base is guanine; (3) which is an adenine derivative showing the most intense light emission in the case where the corresponding base is cytosine; or (4) which is a guanine derivative showing the most intense light emission in the case where the corresponding base is cytosine or thymine / uracil.
Owner:斋藤烈 +1
Nucleotide derivatives and DNA microarray
InactiveCN100372863CEasy to makeSure easy sureSugar derivativesMicrobiological testing/measurementFluorescenceNucleotide
Owner:斋藤烈 +1
Phosphonate prodrug of adenine derivative and application of phosphonate prodrug to medicine
InactiveCN107698621AOrganic active ingredientsGroup 5/15 element organic compoundsAdenine derivativesPharmaceutical drug
Owner:HANGZHOU HEZE PHARMA TECH CO LTD +1
Benzodeazaadenine derivative base and electronic material containing the same
A nucleic acid base for hole transportation in DNAs which does not cause oxidative decomposition; and an artificial DNA molecule which can realize effective hole transportation in DNAs while maintaining the double spiral structure of the DNAs. Provided are: a nucleic acid which contains a benzodeazaadenine derivative base represented by the general formula (I):(wherein R1, R2, R3, R4, R5, and R6 each independently represents hydrogen, amino, mono (lower alkyl) amino, di (lower alkyl) amino, hydroxy, lower alkoxy, halogeno, cyano, mercapto, lower alkylthio, or aryl; and R7 and R8 each independently represents hydrogen or a group bonded to phosphoric acid);and a polynucleotide comprising the nucleic acid.
Owner:JAPAN SCI & TECH CORP
Preparation method of adenine derivative
ActiveCN1786007AHigh yieldHigh purityGroup 5/15 element organic compoundsAdenine derivativesAfter treatment
The present invention relates to a preparation method of adenine derivative. Said method includes the following steps: in non-protonic polar solvent, under the action of catalyst making adenine and phosphonate ester react at 50-150deg.C, then making after-treatment so as to obtain the invented product. The described catalyst at least contains one inorganic alkali and one organic alkali, the described inorganic alkali is selected from carbonate of alkali metal or sodium hydride, and the described organic alkali is selected from alcohol sodium or alcohol potassium of C1-C5.
Owner:ZHEJIANG CHARIOTEER PHARMA
Complex compounds of germanium, methods for producing same, and drugs
ActiveUS20150126726A1Stable in solid stateEasy transferSenses disorderGroup 8/9/10/18 element organic compoundsArginineThreonine
The invention relates to the development of drugs intended for the prophylaxis and / or treatment of viral diseases caused, in particular, by herpes viruses. What are proposed are complex compounds of germanium having the general structural formula:Gex[AD][CA]y[AA]z (I),where AD is a derivative of a nitrogenous base of the purine series that has antiviral activity and can be selected from guanine derivatives, such as acyclovir, valacyclovir, gancyclovir and pencyclovir, or from adenine derivatives, such as vidarabine; CA is a hydroxycarboxylic acid which can be selected from acids such as (but not limited to) citric acid, lactic acid and malic acid; AA is an amino acid which can be selected from various a-amino acids, such as arginine, glycine, lysine and threonine, and where x=1-2, y=2-4 and z=0-2. Complex compounds of germanium have a high level of antiviral and immune-stimulating activity and are readily soluble in water. The above-mentioned compounds are produced by producing an aqueous suspension of germanium dioxide, adding a hydroxycarboxylic acid, a derivative of a nitrogenous base of the purine series and, optionally, but preferably, an amino acid thereto, heating the mixture produced at a temperature of 40-100° C. for 3-14 hours while stirring and removing the water from the solution, thus producing a complex compound of germanium.
Owner:OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU WDS FARMA
Preparation method of adenine derivative
ActiveCN100352823CHigh yieldHigh purityGroup 5/15 element organic compoundsAdenine derivativesAfter treatment
The present invention relates to a preparation method of adenine derivative. Said method includes the following steps: in non-protonic polar solvent, under the action of catalyst making adenine and phosphonate ester react at 50-150deg.C, then making after-treatment so as to obtain the invented product. The described catalyst at least contains one inorganic alkali and one organic alkali, the described inorganic alkali is selected from carbonate of alkali metal or sodium hydride, and the described organic alkali is selected from alcohol sodium or alcohol potassium of C1-C5.
Owner:ZHEJIANG CHARIOTEER PHARMA
Complex compounds of germanium, methods for producing same, and drugs
The invention relates to the development of drugs intended for the prophylaxis and / or treatment of viral diseases caused, in particular, by herpes viruses. What are proposed are complex compounds of germanium having the general structural formula:Gex[AD][CA]y[AA]2 (1),where AD is a derivative of a nitrogenous base of the purine series that has antiviral activity and can be selected from guanine derivatives, such as acyclovir, valacyclovir, gancyclovir and pencyclovir, or from adenine derivatives, such as vidarabine; CA is a hydroxycarboxylic acid which can be selected from acids such as (but not limited to) citric acid, lactic acid and malic acid; AA is an amino acid which can be selected from various a-amino acids, such as arginine, gylcine, lysine and threonine, and where x=1-2, y=2-4 and z=0-2. Complex compounds of germanium have a high level of antiviral and immune-stimulating activity and are readily soluble in water. The above mentioned compounds are produced by producing an aqueous suspension of germanium dioxide, adding a hydroxycarboxylic acid, a derivative of a nitrogenous base of the purine series and, optionally, but preferably, an amino acid thereto, heating the mixture produced at a temperature of 40-100° C. for 3-14 hours while stirring and removing the water from the solution, thus producing a complex compound of germanium.
Owner:OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU WDS FARMA
Adenine kind derivative and its synthesis method
ActiveCN100427488CImprove biological activityEasy to manufactureOrganic chemistryAntipyreticSynthesis methodsTumor necrosis factor alpha
An adenine derivative series is prepared from bromobenze with borate radical through Dimroth rearranging reaction. Its advantage is high activity to suppress proinflammatory factor (tumor necrosis factor alpha) and splitting cell.
Owner:SHANGHAI HETENG FINE CHEM
N6-substituted adenosine derivatives and N6-substituted adenine derivatives and uses thereof
Owner:INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
Calix[4]arene adenine derivative-graphene oxide composite and its preparation method and application
InactiveCN105823764BSimple manufacturing processEase of industrial production in large quantitiesFluorescence/phosphorescenceOxide compositePhotochemistry
![Calix[4]arene adenine derivative-graphene oxide composite and its preparation method and application](https://images-eureka.patsnap.com/patent_img/5adc25bc-1f74-4af1-af10-b5a744762eeb/HDA0000943785520000011.png "Calix[4]arene adenine derivative-graphene oxide composite and its preparation method and application")
![Calix[4]arene adenine derivative-graphene oxide composite and its preparation method and application](https://images-eureka.patsnap.com/patent_img/5adc25bc-1f74-4af1-af10-b5a744762eeb/HDA0000943785520000012.png "Calix[4]arene adenine derivative-graphene oxide composite and its preparation method and application")
![Calix[4]arene adenine derivative-graphene oxide composite and its preparation method and application](https://images-eureka.patsnap.com/patent_img/5adc25bc-1f74-4af1-af10-b5a744762eeb/HDA0000943785520000021.png "Calix[4]arene adenine derivative-graphene oxide composite and its preparation method and application")
Owner:TONGJI UNIV
Methods and compositions for treatment of zika virus infection
Disclosed are 9-deazaaadenine derivatives of the general formula (I)and pharmaceutically acceptable salts thereof, wherein A is OH or NH2, and B is H or NH2. Methods for treating, preventing and / or suppressing a Zika virus infection with the compounds disclosed are also provided. Pharmaceutical compositions comprising the disclosed compounds are also provided. Such pharmaceutical compositions may optionally contain one or more additional active agents.
Owner:BIOCRYST PHARM INC
Adenine derivatives and their use as UV-photoprotective agents
Owner:UNIV PALACKEHO V OLOMOUCI
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