40 results about "Anetoderma" patented technology

Compounds of formula (I)wherein A, B, b, W, X, Y, Z, R1, R2, and R3 have the meanings given in claim 1, pharmaceutical compositions these compounds, and methods of preventing or treating metabolic disorders and / or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia, and diabetes using these compounds.

The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereof for the preparation of a medicament for one or more of: treatment and / or prevention of loss of body weight and body fat, prophylaxis or treatment of cachexia, stimulation of appetite, stimulation of food intake, stimulation of weight gain, or increasing body fat mass, or increasing body lean mass. Another aspect relates to the use of a ghrelin splice variant-like compound for the preparation of a medicament for the prophylaxis or treatment of cancer cachexia in an individual in need of such treatment. Another aspect relates to the use of a ghrelin splice variant-like compound for the preparation of a medicament for prophylaxis or treatment of cachexia in an individual by administering a subcutaneous dosage of said medicament to the individual. A further aspect relates to the use of a ghrelin splice variant-like compound or a pharmaceutically acceptable salt thereof for the preparation of a medicament for stimulation of appetite in an individual by administering a subcutaneous dosage of said medicament to the individual. A further aspect relates to a number of new ghrelin splice variant-like compounds and uses thereof, as well as to pharmaceutical compositions and medical packaging comprising the new ghrelin splice variant-like compounds.

The invention provides for a nutritional composition comprising from 0. 1 to 10 g of eicosapentaenoic acid or a derivative thereof based on 100 kcal of the total composition; and from 0. 1 to 10 g of a phytochemical or a mixture thereof based on 100 kcal of the total composition, for a use as a medicament for the treatment and / or prevention of cachexia and / or anorexia. The composition is particularly useful in the prevention of cachexia and is administered almost without any additional macronutrients in order to avoid a negative impact on the general diet of the patient.

The invention discloses the application of fucoidan in the preparation of drugs for treating cachexia and cancer. The cachexia may be caused by a disease, condition or injury selected from the group consisting of cancer, immunodeficiency disease, infectious disease, autoimmune disease, metabolic disease, and chronic bowel, liver, kidney, lung and Heart disease, anorexia, trauma, burns, malabsorption and anemia. In one embodiment, the medicament of the present invention can be administered to a patient suffering from a disease that may produce cachexia, eg, cancer and the like. In particular, the present invention also provides the application of fucoidan in the preparation of drugs for treating bladder cancer, especially the application in inhibiting bladder cancer tumor growth, tumor angiogenesis, cancer cell migration and invasion.

The present invention relates to drug screening assays, and diagnostic and therapeutic methods for the treatment of body weight disorders, such as obesity, anorexia and cachexia, utilizing the melanocortin 4-receptor (MC4-R) as the target for intervention. The invention also relates to compounds that modulate the activity or expression of the MC4-R, and the use of such compounds in the treatment of body weight disorders.