72 results about "O desmethylvenlafaxine" patented technology

Methods of preparing, and compositions comprising, derivatives of venlafaxine are disclosed. Also disclosed are methods of treating and preventing diseases and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention deficit disorder, attention deficit disorder with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders, obesity and weight gain, incontinence, dementia and related disorders.

A novel salt of O-desmethyl venlafaxine is provided, O-desmethylvenlafaxine succinate. Pharmaceutical compositions, dosage forms and methods of use are also provided.

An oral, highly bioavailable unit dosage form of O-desmethylvenlafaxine succinate (DVS) having a delayed release of at least about one hour and a sustained release over multiple hours to provide a total release of greater than about 85 % within about 12 to about 14 hours is described. In one embodiment, the superbioavailable DVS composition has a delayed release of about two hours and a total release of greater than about 95 % within about 12 to about 14 hours. Use of the formulation in treating depression and reducing the gastrointestinal side-effects of O-desmethylvenlafaxine (ODV) is also described.

The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.

A novel salt of O-desmethylvenlafaxine, O-desmethylvenlafaxine formate, is provided. Pharmaceutical compositions, dosage forms and methods of use are also provided.

The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.

The present invention provides a convenient and efficient process for the preparation of O-desmethylvenlafaxine (ODV) or a salt thereof, comprising the reaction of venlafaxine, or a salt thereof, with a thiourea or a mixture of thioureas.

Methods for preparing crystalline forms of O-desmethylvenlafaxine a described.

Methods for preparing substantially pure O-desmethylvenlafaxine are described.

The present invention provides a convenient and efficient process for the preparation of O-desmethylvenlafaxine (ODV), comprising the reaction of venlafaxine, or a salt thereof, with a thiol reagent such as a dithiol, an aminothiol or an inorganic thiol. The present invention also provides a process for purifying ODV base,said process comprising the steps of mixing crude ODV base with an alcohol to form a suspension and adding acid followed by base to generate ODV base with high purity.

The invention provides a new method for preparation ODV, which comprises the following procedures:1. the compound I(1-[2-amino-1-(4- methoxybenzyl)ethyl] cyclohexanol) is made a demethylation reaction, the adopted catalyzer chooses from mercaptide anion, nickel, cobalt, metal sulphide, diphenylphosphine lithium or trialky borohydrid, the product is further purified to obtain the high pure compound II (1-[2-amino-1-(4-hydroxyphenyl)ethyl] cyclohexanol; 2. the compound II is included by the inclusion agent and is made a N, N-dimethylation reaction with the methylation reagent, the PH value is adjusted to precipitate a large quantity of solids (namely ODV), the inclusion agent is alpha- cyclodextrin hydrate, beta- cyclodextrin hydrate or gamma cyclodextrin hydrate; 3. the precipitated solids are dissolved by the methylene dichloride, are evaporized and are crystallized by the isopropanol. The invention has simple and quick operation, single preparation products, high yields, high purity, and greatly decreased production cost.

Provided are processes and intermediates for the synthesis of O-desmethylvenlafaxine.