The invention relates to the technical field of packaging boxes, in particular to a printing packaging box with a degradation function, which comprises a box body, a clamping plate and a pressing plate. A top cover is clamped on the outer wall of the top of the box body, slots are formed in the two sides of the outer wall of the top of the box body, inserting blocks are welded to the two sides of the outer wall of the bottom of the top cover, and the inserting blocks are inserted into the slots. A clamping groove is formed in the outer wall of one side of each inserting block, a clamping block is slidably connected into each inserting groove and clamped into the corresponding clamping groove, buttons are welded to the ends, located outside the slots, of the clamping blocks, and fixing springs connected with the clamping blocks are welded to the inner walls of one sides of the slots. The printing packaging box with the degradation function has the beneficial effects that the clamping blocks can be clamped in the clamping grooves through the telescopic force of the fixing springs, the top cover can be conveniently fixed to the box body, meanwhile, the top cover can be conveniently opened, adhesive tape is not used for fixing, and repeated use can be achieved; and when the clamping blocks move, limiting blocks slide in limiting grooves, the clamping blocks can move in parallel, and the deflection phenomenon of the clamping blocks in the moving process is prevented.