1results about How to "Avoid affecting the treatment effect" patented technology

This invention relates to the field of functional polymer materials and discloses a method for preparing an antibacterial composite nanofiber material with cascade activity. The method includes: dissolving a gold precursor in a solvent; adding a polymer to obtain a polymer solution; reacting with a sodium borohydride solution; electrospinning to obtain an Au composite nanofiber membrane; dissolving TCPP in a mixed solvent of N-N-dimethylformamide / ethanol; adding Cu₂O, polyvinylpyrrolidone, and trifluoroacetic acid; reacting to obtain Cu-TCPP; adding the Cu-TCPP dispersion to the surface of the Au composite nanofiber membrane under vacuum filtration; and drying. In the antibacterial composite nanofiber material of this invention, Cu-TCPP is stably anchored on the surface of the nanofiber membrane, preventing excessive encapsulation of Cu-TCPP and thus reducing the therapeutic effect. In a weakly alkaline environment conducive to infection, this antibacterial composite nanofiber material can utilize Au nanozymes as initial enzymes to continuously catalyze the production of gluconic acid and H₂O₂ from glucose, thereby activating the POD-Like activity of Cu-TCPP to catalyze the generation of hydroxyl radicals to kill bacteria.