The invention relates to a self-adhesion reactive, water-swellable and waterproof sealing material and a production method thereof. Butyl rubber is used as the matrix of the self-adhesion reactive, water-swellable and waterproof sealing material, and other raw materials comprise polyisobutene, amorphous alpha-olefin copolymer, desulfuration gypsum, bentonite, tackifying resin, lithium chloride, calcium chloride, calcium stearate and a crosslinking agent, and counted in parts by weight, the proportions of the components are as follows: 50-100 parts of butyl rubber (IIR), 50-120 parts of polyisobutene, 5-10 parts of amorphous alpha-olefin copolymer, 100-180 parts of desulfuration gypsum, 80-120 parts of bentonite, 12-25 parts of tackifying resin, 0.1-2 parts of lithium chloride, 1-10 parts of calcium chloride, 0.08-1.2 parts of calcium stearate and 0.5-3 parts of crosslinking agent. By adopting the self-adhesion reactive, water-swellable and waterproof sealing material provided by the invention, the utilization range of the solid waste desulfuration gypsum is expanded, the problem that the existing waterproof sealing product cannot generate a chemical crosslinking reaction with concrete is solved as well, the two components are organically combined to turn waste into wealth, and the self-adhesion reactive, water-swellable and waterproof sealing material with a self-recovery function is innovatively provided.