The invention provides a replaceable chemical device fixing steel frame which comprises a movable seat, movable brake wheels, an inverted-U-shaped portal frame, first threaded holes, fixed supporting rods, pluggable rotating supporting seat structures, a liftable pushing anti-skid plate structure, a horizontal detection fixing rod structure, fixable reinforcing storage seat structures, a transverse supporting rod, inverted-L-shaped rotating frames, climbing rods, second threaded holes, connecting rods and push rods. According to the replaceable chemical device fixing steel frame provided by the invention, a lifting anti-skid plate, second shielding plates, a deep groove ball bearing, a T-shaped threaded rod, a rotating disc, the inverted-U-shaped portal frame and the first threaded holes are arranged in a matched mode, the rotating disc can be grabbed to rotate in the using process, meanwhile, the T-shaped threaded rod is driven to rotate, the T-shaped threaded rod and the inverted-U-shaped portal frame are arranged in a threaded connection mode, and the lifting anti-skid plate is pushed to ascend, so that the lifting anti-skid plate pushes chemical equipment to ascend and descend, and sliding equipment pushing work is facilitated in the replacement process.