The invention discloses an ampoule bottle washing, wetting filling and sealing integrated device which comprises a main machine shell, a fixed disc, a rotary disc, a rotary disc driving motor, a stepping motor lead screw sliding table, a washing, wetting and filling integrated system and a rotating and melt sealing system. The washing, wetting and filling integrated system and the rotary melting and sealing system are arranged in sequence in the rotating direction of the rotary disc. The fixed disc is fixed on the main machine shell through a support column, the rotary disc is positioned abovethe fixed disc, a self-adaptive clamping mechanism is arranged along the circumferential direction of the rotary disc, and an ampoule bottle is centered and fixed through the self-adaptive clamping mechanism; the washing, wetting and filling integrated system comprises a washing, wetting and filling lifting arm, and the washing, wetting and filling lifting arm is sequentially provided with a cleaning mechanism, a pre-wetting mechanism and a filling mechanism along the rotating direction of the rotary disc; and the rotating and melt sealing system comprises a rotating mechanism and a melt sealing mechanism. Washing, wetting and filling are combined, filling of protective gas can be carried out during filling for protection, the self-adaptive clamping mechanism is adopted to be matched witha fire nozzle lifting sensor to realize synchronous operation of ampoule bottles of different specifications; negative pressure is adopted to suck the ampoule bottles for rotating and melt sealing, and semi-spherical melt sealing is realized without waste.