The invention relates to a quick sealing locking device for a pressure meter. The device comprises columns, thread slide blocks, a slide block base, a sealing air column, fixing parts, an upper die block, a lifting tenon part, an air cylinder, a lower die block, a pneumatic switch and a pneumatic piston rod; the upper die block is connected with the lower die block through the columns, and the columns are evenly distributed at the four corners of the lower die block; the air cylinder is arranged among the four columns, the bottom of the air cylinder is arranged on the lower die block through the fixing parts, and the slide block base is arranged in the center of the upper die block; an inner hole is formed in the center of the slide block base, a pressure meter connector is assembled in the upper portion of the inner hole, and a sealing air column is arranged on the lower portion of the inner hole; an oil inlet pipe is arranged at the bottom, vertical to the sealing air cylinder, of each sealing air cylinder, the thread slide blocks are arranged on the portions, in the slide block base, of the two sides of the inner hole, and two magnets are symmetrically embedded in the thread slide blocks; an air cylinder piston rod of the air cylinder pushes and acts on the lifting tenon part. According to the quick sealing locking device, the labor efficiency of operators can be effectively improved, the productivity is improved, the quality of the product is guaranteed, and meanwhile the yield is increased.