The invention relates to the technical field of liquid
chromatography-
mass spectrometers, and discloses a
temperature control device of a liquid
chromatography tandem
mass spectrometer, which comprises a column oven, a partition plate is arranged in the column oven, the partition plate divides the interior of the column oven into an operation chamber and a
refrigeration chamber, a heating box and a heat exchange
assembly are arranged in the operation chamber, and the
refrigeration chamber is communicated with the heating box. A
refrigeration box is arranged in the refrigeration chamber; the heat exchange
assembly comprises a fixing frame fixed to the partition plate, a sleeve is arranged on one side of the fixing frame, fixing plates are oppositely arranged at the two ends of the sleeve, the fixing plates are fixedly connected to the fixing frame, the chromatographic columns are fixed to the
peripheral side of the sleeve, a plurality of air supply outlets are formed in the
peripheral side wall of the sleeve, one end of the sleeve communicates with the heating box, and a
cold air pipe is rotationally connected into the sleeve. The end, away from the heating box, of the
cold air pipe extends out of the sleeve and communicates with the refrigerating box. Switching of
cold air and hot air is achieved through the heat exchange
assembly, accurate and rapid regulation and control of the temperature in the
chromatographic column are achieved, and therefore the separation effect of the
chromatographic column is improved.