The invention discloses a preparation method of a ceramic grinding body for gypsum grinding. The preparation method comprises the following steps of a, selecting the powder, using BaO (barium oxide),TiC (titanium carbide), Mo2C (molybdenum carbide), ZrO2 (zirconium dioxide), Cr2C3 (Chromium carbide) and TaC (tantalum carbide) as the raw materials, preparing acetic acid with concentration of 80% to 90% as a solvent, pouring into the raw materials, mixing with the raw materials, fully impregnating for 3 to 6h, mixing, and controlling the time within 0.5h, so as to obtain a grinding medium; b, drying the raw materials in step a, mixing with coke, selecting spheres, and fully grinding, wherein the ratio of spheres to material is 3:5, the rotation speed of sphere grinding is 300 to 450rpm, andthe duration of sphere grinding is 30 to 48h; c, screening the mixture after sphere grinding, wherein the sieve hole is 50 to 150 meshes; d, putting the screened mixture into a die, and pressing intothe blank at the pressure of 350 to 550MPa; e, heating the fetched blank, cooling the heated and formed blank, cutting after cooling, grinding and polishing. The prepared grinding body has higher hardness and longer service life.