The invention provides a multifunctional express delivery send-receive cabinet and an application method thereof, and belongs to the intelligent express delivery technical field; the express delivery send-receive cabinet comprises a cabinet body, a box group, cameras, a touch screen, an ID card sensor, a fingerprint recognizer, a bar-code scanner, a bar code generator, an intelligent control box, an alarm, a matching ID card, an internet mobile communication device, and a client end; the box group is nested in the cabinet body; the cameras are respectively fixed on two sides of the top of the cabinet body; the touch screen is nested in the cabinet body center, and fixedly arranged on the intelligent control box; the ID card sensor, the fingerprint recognizer, the bar-code scanner, and the bar code generator are fixed on the intelligent control box, and positioned below the touch screen; the internet mobile communication device is arranged in the intelligent control box; the alarm is fixedly arranged on the cabinet body. The multifunctional express delivery send-receive cabinet is various in functions, suitable for various express piece kinds, can improve express delivery send-receive efficiency, and can save space.