The invention belongs to the technical field of information security, and particularly relates to a color image encryption method based on cellular neural network hyperchaos and a DNA sequence. The method provided by the invention comprises the steps of separating red, green and blue three primary color components of a color plaintext image; updating and generating parameters and initial values of a six-order cellular neural network hyperchaotic system and a Logistic-Sine mapping system through the plaintext image, respectively carrying out iterative operation on the two chaotic systems, and obtaining red, green and blue components of an encrypted image according to a DNA encoding rule and a DNA decoding rule; and finally, changing the pixel values of the encrypted image through key stream and a bitwise XOR operation to obtain a final ciphertext image. The decryption is a reverse operation of the encryption process. Compared with the existing image encryption method, the color image encryption method provided by the invention has the advantages of high security, good encryption effect, strong robustness, no information loss and the like, and thus being capable of being widely used in military, remote sensing, remote medical treatment, commerce and other fields.