The invention discloses a three-dimensional heterogeneous oil-reservoir multi-well-pattern mode water flooding physical simulation experiment device. The three-dimensional heterogeneous oil-reservoirmulti-well-pattern mode water flooding physical simulation experiment device comprises a reservoir simulation system, an injection system and an experimental measurement system, wherein the injectionsystem and the experimental measurement system are separately connected with the reservoir simulation system. The reservoir simulation system comprises an experiment box, an insulating filter screen and a measurement electrode. The insulating filter screen is detachably arranged to divide the experiment box into multiple layers; the injection system comprises an injection pump, an oil-and-water storage tank, a pressure gauge and a multiported valve, wherein the injection pump, the oil-and-water storage tank, the pressure gauge and the multiported valve are connected in sequence; the oil-waterstorage tank is connected with each layer of the experiment box through the multiported valve and an injection pipeline; and the experimental measurement system comprises a multi-channel resistance measurement instrument and a flow measurement system, wherein the multi-channel resistance measurement instrument is connected with the measuring electrode, and the flow measurement system is connectedwith each layer of the experiment box through discharging pipelines. According to the three-dimensional heterogeneous oil-reservoir multi-well-pattern mode water flooding physical simulation experiment device, multi-layer filling and leveling degree is ensured, the development of an interlayer can be more accurately simulated, the oil-and-water production can be measured in layers under the simulated multi-well-pattern mode, and the resistance is measured in real time to obtain the saturation distribution.