The invention provides an injection-production relation optimizing and adjusting method for a well group and belongs to the field of oil field development projects. According to the injection-production relation optimizing and adjusting method for the well group, a three-dimensional phase-control geologic model of a block to be adjusted is established by drawing a depositional microfacie distribution diagram, a sand group structural map, an effective thickness contour diagram, a porosity contour diagram and a permeability contour diagram of the block to be adjusted, the remaining oil saturation distribution state of the well group in the block to be adjusted is determined, and the injection-production relation of the well group in the block to be adjusted is optimized and adjusted. Through depositional microfacie control, the geologic model which is more similar to the actual stratum is established, the influence of depositional microfacies is fully considered during numerical simulation of the well group, permeability saturation curves corresponding to the percolation characteristics of different depositional microfacies are provided for the different depositional microfacies, and the simulated remaining oil distribution states in different facie belts are more accurate. Well group adjustment parameters obtained on the basis are more reliable, and a more objective theoretical basis is provided for continuous and efficient development of oil fields and scientific decision-making.