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32results about How to "Convenient for patient" patented technology

Method of automatically controlling a respiration system and a corresponding respirator

A method of automatically controlling a respiration system for proportional assist ventilation with a control device and with a ventilator. An electrical signal is recorded by electromyography with electrodes on the chest in order to obtain a signal uemg(t) representing the breathing activity. The respiratory muscle pressure pmus(t) is determined by calculating it in the control unit from measured values for the airway pressure and the volume flow Flow(t) as well as the patient's lung mechanical parameters. The breathing activity signal uemg(t) is transformed by means of a preset transformation rule into a pressure signal pemg(uemg)(t)) such that the mean deviation of the resulting transformed pressure signal pemg(t) from the respiratory muscle pressure pmus(t) is minimized. The respiratory effort pressure ppat(t) is determined as a weighted mean according to ppat(t)=a·pmus(t)+(1−a)·pemg(t), where a is a parameter selected under the boundary condition 0≦a≦1. The airway pressure paw(t) to be delivered is calculated as a function of preselected degrees of assist VA (Volume Assist) and FA (Flow Assist) by sliding adaptation as
paw(ti)=k0+j=1nkj·paw(ti-j)+j=0nhj·ppat(ti-j)
wherein ti is a current point in time and ti−j, wherein j=1, . . . , n, are previous points in time of a periodical time-discrete sampling, and kj and hj, wherein j=1, . . . , n are parameters dependent on resistance (R), elastance (E), positive end-expiratory pressure (PEEP), intrinsic PEEP (iPEEP), Volume Assist (VA) and Flow Assist (FA) and the sampling time Δt, and the ventilator is set by the control unit so as to provide this airway pressure paw(ti)
Owner:DRAGERWERK AG

Stimulation of penis erection

A penis erection stimulation system comprises one or more infusion needles disposed within and implanted along with one or more housings adjacent the patient's left and right corpora cavernosa. A reservoir and a pump are also implanted inside the patient's body to supply the infusion needle with infusion liquid. A drive unit also adapted for implantation inside the patient's body is arranged for advancing and retracting the tip end of the infusion needle such that it penetrates the housing in at least one penetration area, preferably at least in two different penetration areas either simultaneously or in immediate time succession, thereby injecting drugs along with the infusion liquid into the patient's body for stimulating penis erection. The outer wall of the housing accommodating the infusion needle comprises at least one door in the penetration area or areas. A drive is connected to the door for actively opening the door so as to allow for the infusion needle to be advanced through the opened door. The door may comprise a flap, such as a resilient, normally closed flap. It is particularly preferred if the drive connected to the door forms part of the drive unit coupled to the infusion needle. More specifically, the arrangement may be such that advancement of the infusion needle by means of the drive unit simultaneously causes the drive to open the door.
Owner:FORSELL PETER

Method, sequences, compositions and kit for detection of changes in the promoter of the gene htert

The present invention refers to a method for the detection of the c.-124 C>T and c.-146 C>T mutations in Htert gene promoter. The referred method uses a reaction composition that comprises primers for amplification and probes for genotyping.
Another aspect of this invention refers the primers and probes used in performing the aforementioned method with sequences, identified as SEQ ID nr.1 to SEQ ID nr.6, that display high specificity for these mutations, as well as compositions that contain them.
The present invention further refers to a kit comprising the above mentioned compositions for detecting mutations c.-124 C>T and c.-146 C>T mutations in Htert gene promoter by conducting the present method invention.
The method, gene sequences, compositions and kit of the present invention can be advantageously used for detecting trace amounts of c.-124 C>T and c.-146 C>T mutations, present in biological samples due to its high sensitivity and specificity for such mutations.
The present invention can therefore be applied in early detection, identification, detection of recurrence or prediction and monitoring of diseases associated with those mutations, such as bladder carcinomas, thyroid carcinomas, squamous cell carcinoma, basal cell carcinomas, skin cancer, central nervous system cancers and hepatocellular carcinoma, among others and eventually provide the basis for appropriate treatment setting.
Thus, the present invention falls within the technical field of medicine, pharmaceutics, molecular biology, biochemistry, and human related genetics.
Owner:IPATIMUP INST DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIV DO PORTO
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