A large screen information interactive system and method are disclosed, including a computer 3, a projector 4, a pointer equipment 2, and an interactive whiteboard 1 including at least one display panel 6 on the same plane and at least one electronic writing board 5 used for sensing and receiving an operational signal of the pointer equipment 2. The at least one electronic writing board 5 is connected with the computer 3 through a serial port, a USB port, a wireless communication module, or a bluetooth module. The signal of the pointer equipment 2 collected from the electronic writing board 5 is processed by the computer 3. A processed displayed image is projected onto the interactive whiteboard 1 by the projector 4. When one point on the electronic writing board 5 is written, position and state information signals of the written point are transferred to the computer for converting, and the data is processed according to display attributes and operational commands. A whiteboard coordinate is converted into a screen coordinate corresponding to a display. A state of the pointer equipment 2 is converted into a mouse state, so as to updating the screen data. Screen signals are projected onto the interactive whiteboard 1 by the projector 4. Therefore, display and writing problems with an ultra-large screen are resolved, extending the application scope of the interactive whiteboard.