The invention provides a safe and reliable mouse capture device, and belongs to the technical field of mouse capture. The device comprises a cage body, opening and closing doors are connected to the two ends of the cage body, a slippery trap is arranged inside the cage body, the upper end of the slippery trap is fixed through a cross rod, an opening of the slippery trap faces the opening and closing doors, and a feeding alluring hook is arranged at the rear end of the slippery trap. The slippery trap can trap a mouse, make it convenient to remove the mouse in the cage body in the later periodand prevent the mouse against contact with a capturer; the feeding alluring hook has an effect of trapping the mouse and can increase the success rate of the mouse capture of the device; the opening and closing doors are arranged at both ends of the cage body, the cage body of which the two ends are through creates a dark environment, and alluring of the device to the mouse can be improved, and the vigilance of the mouse in the cage body can be lowered. The safe and reliable mouse capture device has a good effect of trapping the mouse, the capturing success rate is high, after capturing is completed, the capturing interference on surrounding mice is small, the treatment of the captured mouse is high in convenience, and the safety is high.