56results about How to "Improve penetrability" patented technology

A delivery system includes a rigid shaft, an imaging core, and an interventional core. The rigid delivery shaft has a proximal end, an angled distal tip, and an axial passage therethrough. The imaging core comprises an ultrasound imaging insert disposed within the axial passage. The imaging insert has an ultrasound array within a distal portion thereof, wherein the ultrasound array is tilted relative to a shaft axis. The interventional core comprises a curved ablation needle coupled to the rigid shaft. An angle of needle curvature may be inversely proportional to the ultrasound array tilt and tip angle.

Hypotonic formulations were evaluated for delivering water-soluble drugs and for drug delivery with muco-inert (that is, non-adhesive) mucus-penetrating nanoparticles (MPP). Hypotonic formulations markedly increased the rate at which drugs and MPP reached the epithelial surface, including deep into the vaginal folds. Minimally hypotonic formulations, preferably ranging from 20-220 mOsm/kg, provided rapid and uniform delivery of MPP to the entire vaginal surface, with minimal risk of epithelial toxicity. Data also show that there is a higher osmolality in the colon, such that vehicles with an osmolality above that of blood plasma (generally considered isotonic at ˜300 mOsm/kg), still lead to improvements in distribution in the colon due to rapid, osmotically-induced fluid absorption. The range for improved colon distribution with a hypotonic vehicle in the colon is ˜20 mOsm/kg-450 mOsm/kg.

Ink-jet printing with fixing ability, while maintaining printing qualities such as OD and sharpness at high levels, can be achieved by using an ink containing a self-dispersing pigment as a coloring material without using a dispersant and a treating liquid for insolubilizing the coloring material. Benalkonium chloride (G50) having one cationic group in the molecule is used as the insolubilizing agent in the treating liquid. As a result, the cationic group is completely bonded to the anionic group of the pigment particle, thereby producing a cohesive force between pigment particles.

A kinetic energy rod warhead including a plurality of sections each enclosing a plurality of projectile and an explosive charge partially surrounding the projectiles defining a primary projectile firing direction. The firing direction of each section is different for isotropically deploying the projectiles.

Delivery systems, and methods using the same, having an ultrasound viewing window for improved imaging and a needle for ablation treatment of target tissues. In an embodiment, the target tissue is a fibroid within a female's uterus. In an embodiment, the delivery system includes a rigid shaft having a proximal end, a distal end, and an axial passage extending through the rigid shaft. In an embodiment, the axial passage is configured for removably receiving the ultrasound imaging insert having an ultrasound array disposed a distal portion.

An artificial bone capable of being absorbed and replaced by an autogenous bone, which comprises a cylindrical body obtained by rolling a sheet-shaped apatite/collagen composite, a hollow center portion of the cylindrical body penetrating from one end surface to the other end surface having a diameter of 100-1000 μm.

A pretreatment agent for electroless plating is provided, which includes: a fluorine compound; a surfactant; and at least one solvent selected from ethylene-based glycol butyl ethers of formula: C₄H₉—(OC₂H₄)_m—OH where m is an integer of 1 to 4, and propylene-based glycol butyl ethers of formula: C₄H₉—(OC₃H₆)_n—OH where n is an integer of 1 to 4. Also provided are a method for pretreating a substrate to be used for a printed wiring board, and a process for producing a printed wiring board, both of which include using a pretreatment agent for electroless plating as described above.

The invention relates to a method for producing membrane, in particular gas separation membrane, wherein the membrane comprises a selective separating layer. The following steps are carried out: a) a polymer solution is produced from at least one polymer and at least one polyglycol ether, b) the polymer solution is cast into a film, c) in a further step, the selective separating layer is produced from the film, preferably by drying. The invention, among other things, further relates to a membrane, in particular gas separation membrane, comprising a selective separating layer.

A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising:

• • a step A of obtaining an adhesive agent layer composition comprising oxybutynin hydrochloride as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, a sterol, an organic acid, and a tackifier;
  • a step B of heating the adhesive agent layer composition at a temperature in a range from 55 to 70° C. for 1 to 24 hours; and
  • a step C of cooling the heated adhesive agent layer composition to a temperature lower than room temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.

The invention provides a bonding structure of a wind turbine foundation steel ring and concrete and a construction method and belongs to the technical field of wind turbine foundation construction. The bonding structure comprises the wind turbine foundation steel ring and concrete foundations. The lower end of the wind turbine foundation steel ring is arranged in the concrete foundations. The spaces between the inner wall of the wind turbine foundation steel ring and the concrete foundations, between the outer wall of the wind turbine foundation steel ring and the concrete foundations and between an end plate and the concrete foundations are filled with modified epoxy layers respectively. The construction method comprises the step of pouring of modified epoxy. According to the bonding structure of the wind turbine foundation steel ring and the concrete and the construction method, the spaces between the inner wall of the wind turbine foundation steel ring and the concrete foundations, between the outer wall of the wind turbine foundation steel ring and the concrete foundations and between the end plate and the concrete foundations are filled with the modified epoxy layers respectively, so that the wind turbine foundation steel ring and the concrete foundations are bonded into a whole through the modified epoxy, and good toughness and impact resistance are achieved. Therefore, the good effect of stress transfer of the wind turbine foundation steel ring is achieved, and safe operation of a wind turbine generator system is ensured.

This invention belongs to the chemical field, which is related to the fields of pharmaceutical preparations and cosmetic, especially to asiaticoside-liposome and its use for preparing pharmaceutical preparations and cosmetic. In this invention, asiaticoside and lipid components are fused by heating or dissolved in organic solvents, then treated with the rotary thin layer evaporation technique, hydrated by adding aqueous solution under shaking to afford lipid dispersing aqueous solution, and then treated by using the technics of sonication, homogeneous emulsification, microjet and extruding filtration to enwrap asiaticoside in the middle of liposomal bilayer membranes to form the hydrophilic asiaticoside-liposome. Asiaticoside-liposome of this invention can enhance the stability, skin penetrability and hydrophilicity of asiaticoside, it can be used for the preparation of cosmetic and pharmaceutical preparations especially skin-penetrated pharmaceutical preparations, and it is more convenient and easy to prepare skin-penetrated pharmaceutical preparations and cosmetic containing asiaticoside.

Graphene serving as the cathode of an X-ray tube, and a high-efficiency graphene cathode field emission X-ray tube. The graphene cathode field emission X-ray tube is high in conversion efficiency and less in stray radiation, reduces radiation dosage acting upon human body when used in the fields of medical treatment, security inspection and the like; the graphene cathode field emission X-ray tube is easy to realize a micro-focus X-ray tube, strong in emissive power and high in voltage resistance, and can be applied to the fields of semiconductor detection, industrial flaw detection and the like; in addition, the graphene cathode field emission X-ray tube is good in controllability, free from cathode heating. The graphene cathode field emission X-ray tube also has the characteristics of good stability and long service life.

A wafer having a plurality of through holes is provided, and a glass wafer is disposed on the wafer. A plate having a plurality of concave cavities is disposed on the glass wafer, wherein the concave cavities corresponding to the through holes of the wafer so that a part of the plate corresponding to the through holes is not in contact with the glass wafer. A voltage source is provided, and two electrodes thereof respectively have electrical connections to the wafer and the plate. The wafer and the glass wafer are bonded to each other by the anodic bonding method so that a plurality of optical device caps are formed.

Disclosed are: a composition for hard tissue repair with excellent penetrability to an adherend such as a cancellous bone and excellent adhesion to an adherend, which comprises a monomer (A), a polymer (B), a polymerization initiator (C) and a contrast medium (X) having a volume mean particle diameter of 3 μm or more; and a kit for hard tissue repair having members in which the components of the monomer (A), the polymer (B), the polymerization initiator (C) and the contrast medium (X) contained in this composition for hard tissue repair are encased in three or more divided groups in an optional combination.