60results about How to "Improve penetrability" patented technology

A delivery system includes a rigid shaft, an imaging core, and an interventional core. The rigid delivery shaft has a proximal end, an angled distal tip, and an axial passage therethrough. The imaging core comprises an ultrasound imaging insert disposed within the axial passage. The imaging insert has an ultrasound array within a distal portion thereof, wherein the ultrasound array is tilted relative to a shaft axis. The interventional core comprises a curved ablation needle coupled to the rigid shaft. An angle of needle curvature may be inversely proportional to the ultrasound array tilt and tip angle.

Hypotonic formulations were evaluated for delivering water-soluble drugs and for drug delivery with muco-inert (that is, non-adhesive) mucus-penetrating nanoparticles (MPP). Hypotonic formulations markedly increased the rate at which drugs and MPP reached the epithelial surface, including deep into the vaginal folds. Minimally hypotonic formulations, preferably ranging from 20-220 mOsm / kg, provided rapid and uniform delivery of MPP to the entire vaginal surface, with minimal risk of epithelial toxicity. Data also show that there is a higher osmolality in the colon, such that vehicles with an osmolality above that of blood plasma (generally considered isotonic at ˜300 mOsm / kg), still lead to improvements in distribution in the colon due to rapid, osmotically-induced fluid absorption. The range for improved colon distribution with a hypotonic vehicle in the colon is ˜20 mOsm / kg-450 mOsm / kg.

A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and / or salt thereof as a drug, an acrylic-based polymer and / or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.

An artificial bone capable of being absorbed and replaced by an autogenous bone, which comprises a cylindrical body obtained by rolling a sheet-shaped apatite / collagen composite, a hollow center portion of the cylindrical body penetrating from one end surface to the other end surface having a diameter of 100-1000 μm.

A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising:a step A of obtaining an adhesive agent layer composition comprising oxybutynin hydrochloride as a drug, an acrylic-based polymer and / or a rubber-based polymer as an adhesive base agent, liquid paraffin, a sterol, an organic acid, and a tackifier;a step B of heating the adhesive agent layer composition at a temperature in a range from 55 to 70° C. for 1 to 24 hours; anda step C of cooling the heated adhesive agent layer composition to a temperature lower than room temperature at an average rate of temperature drop of 1 to 20° C. / hour, thereby obtaining the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.

A wafer having a plurality of through holes is provided, and a glass wafer is disposed on the wafer. A plate having a plurality of concave cavities is disposed on the glass wafer, wherein the concave cavities corresponding to the through holes of the wafer so that a part of the plate corresponding to the through holes is not in contact with the glass wafer. A voltage source is provided, and two electrodes thereof respectively have electrical connections to the wafer and the plate. The wafer and the glass wafer are bonded to each other by the anodic bonding method so that a plurality of optical device caps are formed.

Delivery systems, and methods using the same, having an ultrasound viewing window for improved imaging and a needle for ablation treatment of target tissues. In an embodiment, the target tissue is a fibroid within a female's uterus. In an embodiment, the delivery system includes a rigid shaft having a proximal end, a distal end, and an axial passage extending through the rigid shaft. In an embodiment, the axial passage is configured for removably receiving the ultrasound imaging insert having an ultrasound array disposed a distal portion.

A pretreatment agent for electroless plating is provided, which includes: a fluorine compound; a surfactant; and at least one solvent selected from ethylene-based glycol butyl ethers of formula: C4H9—(OC2H4)m—OH where m is an integer of 1 to 4, and propylene-based glycol butyl ethers of formula: C4H9—(OC3H6)n—OH where n is an integer of 1 to 4. Also provided are a method for pretreating a substrate to be used for a printed wiring board, and a process for producing a printed wiring board, both of which include using a pretreatment agent for electroless plating as described above.

A preparing method for coating polymethylmethacrylate (PMMA) particles with silicon dioxide is disclosed and includes the following steps of: preparing a silicon dioxide solution by mixing a silicon dioxide powder and a solvent; adding a dispersant-and-interface-modifier agent into the silicon dioxide solution; performing a wet grinding to the silicon dioxide solution with the dispersant-and-interface-modifier agent so as to obtain a plurality of nano-sized silicon dioxide particles with negative charge; performing an interface modification to a plurality of PMMA particles to be charged with positive charge; adding the PMMA particles into the silicon dioxide solution; making the PMMA particles adsorb the nano-sized silicon dioxide particles; and performing a solid-liquid separation process to the silicon dioxide solution so as to obtain the chemical composite particles.

The invention provides a bonding structure of a wind turbine foundation steel ring and concrete and a construction method and belongs to the technical field of wind turbine foundation construction. The bonding structure comprises the wind turbine foundation steel ring and concrete foundations. The lower end of the wind turbine foundation steel ring is arranged in the concrete foundations. The spaces between the inner wall of the wind turbine foundation steel ring and the concrete foundations, between the outer wall of the wind turbine foundation steel ring and the concrete foundations and between an end plate and the concrete foundations are filled with modified epoxy layers respectively. The construction method comprises the step of pouring of modified epoxy. According to the bonding structure of the wind turbine foundation steel ring and the concrete and the construction method, the spaces between the inner wall of the wind turbine foundation steel ring and the concrete foundations, between the outer wall of the wind turbine foundation steel ring and the concrete foundations and between the end plate and the concrete foundations are filled with the modified epoxy layers respectively, so that the wind turbine foundation steel ring and the concrete foundations are bonded into a whole through the modified epoxy, and good toughness and impact resistance are achieved. Therefore, the good effect of stress transfer of the wind turbine foundation steel ring is achieved, and safe operation of a wind turbine generator system is ensured.