The invention provides a vacuum pumping-out bottle. The bottle comprises a barrel body, a soft containing structure, a pump core, a shoulder sleeve, a press cap and an outer cover, wherein the shoulder sleeve is connected with the open end of the barrel body; the soft containing structure is connected with the shoulder sleeve; the pump core is installed inside the shoulder sleeve; the press cap isconnected with the pump core; and the shoulder sleeve is connected with the outer cover. According to the structure, movement of a piston is not needed, and when the pump core is pressed to pump outcontent liquid, the soft containing structure contracts, so that the content liquid can be stably pumped out, and the problem that the piston is stuck is solved. The bottle has simple structure and reliable technology. A smearing structure is installed on the press cap, and is convenient and practical. A plurality of pump core joints can also be arranged on the shoulder sleeve, and connected withdifferent pump cores and soft containing structures respectively, different content liquids are put into different soft containing structures, so that various use requirements of users can be met, thecost is low, and the bottle is portable.